呼吸不全・睡眠呼吸障害[業績]

• 2023年度

  1. Tashima N, Matsumoto H, Nishi K, Terada S, Kogo M, Nomura N, Morimoto C, Sunadome H, Nagasaki T, Oguma T, Nakatsuka Y, Murase K, Kawaguchi T, Tabara Y, Chin K, Sonomura K, Matsuda F, Hirai T. Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study. Allergol Int 2024;73(1):65-70. doi:10.1016/j.alit.2023.04.005
  2. Terada S, Matsumoto H, Nishi K, Kogo M, Nomura N, Tashima N, Morimoto C, Sunadome H, Nagasaki T, Oguma T, Nakatsuka Y, Murase K, Kawaguchi T, Tabara Y, Sonomura K, Matsuda F, Chin K, Hirai T. Association of lower plasma citric acid with prolonged cough: the Nagahama study. Sci Rep. 2023;13(1):13921. doi:10.1038/s41598-023-40878-z
  3. Tabara Y, Matsumoto T, Murase K, Setoh K, Kawaguchi T, Nakayama T, Wakamura T, Hirai T, Chin K, Matsuda F, group and the N study. Sleep-related factors associated with masked hypertension: the Nagahama study. J Hypertens 2023;41(8):1298-1305. doi:10.1097/hjh.0000000000003466
  4. Nakatsuka Y, Murase K, Sonomura K, Tabara Y, Nagasaki T, Hamada S, Matsumoto T, Minami T, Kanai O, Takeyama H, Sunadome H, Takahashi N, Nakamoto I, Tanizawa K, Handa T, Sato TA, Komenami N, Wakamura T, Morita S, Takeuchi O, Nakayama T, Hirai T, Kamatani Y, Matsuda F, Chin K. Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study. Sci Rep 2023;13(1):12735. doi:10.1038/s41598-023-40002-1
  5. Tanabe N, Sato S, Shimada T, Kaji S, Shiraishi Y, Terada S, Maetani T, Mochizuki F, Shimizu K, Suzuki M, Chubachi S, Terada K, Tanimura K, Sakamoto R, Oguma T, Sato A, Kanasaki M, Muro S, Masuda I, Iijima H, Hirai T. A reference equation for lung volume on computed tomography in Japanese middle-aged and elderly adults. Respir Investig 2024;62(1):121-127. doi:10.1016/j.resinv.2023.12.004
  6. Oshima Y, Sato S, Chen-Yoshikawa TF, Nakajima D, Yoshioka Y, Hamada R, Kajimoto T, Otagaki A, Nankaku M, Tanabe N, Ikeguchi R, Date H, Matsuda S. Perioperative changes in radiographic density in erector spinae muscle and mortality after lung transplantation. Respir Med 2023;221:107482. doi:10.1016/j.rmed.2023.107482
  7. Nishi K, Nagasaki T, Matsumoto H, Oguma T, Terada S, Nomura N, Kogo M, Tashima N, Sunadome H, Murase K, Matsumoto T, Kawaguchi T, Tabara Y, Matsuda F, Sato S, Chin K, Hirai T. Increased blood eosinophils and airflow obstruction as new-onset asthma predictors in the elderly: The Nagahama study. Allergol Int 2023: S1323-8930(23)00114-4. doi:10.1016/j.alit.2023.11.002
  8. Mori R, Handa T, Ohsumi A, Ikezoe K, Tanizawa K, Uozumi R, Tanabe N, Oguma T, Sakamoto R, Hamaji M, Nagajima D, Yutaka Y, Tanaka S, Yamada Y, Oshima Y, Sato S, Fukui M, Date H, Hirai T. Evaluation of bone mineral density in lung transplant recipients by chest computed tomography. Respiration 2023; (in press) doi:10.1159/000535269
  9. Nagasaki T, Miyake M, Sato S, Murase K, Kawaguchi T, Matsumoto T, Nakatsuka Y, Mori Y, Ikeda H, Sunadome H, Takahashi N, Togawa J, Kanai O, Uiji S, Wakamura T, Tabara Y, Tsujikawa A, Mastuda F, Hirai T, Chin K. Associations between nocturnal hypoxemia and retinal nerve fiber layer thinning: The Nagahama Study. Ann Am Thorac Soc 2023; (in press)
  10. Shirata M, Nishioka K, Hamao N, Oi I, Hidaka Y, Ibi Y, Imai S, Sato S, Hirai T, Ito I. Impact of wearing a surgical facemask during exercise on dyspnea in patients with chronic pulmonary infections: a randomized crossover study. Respir Med 2023;107453. doi:10.1016/j.rmed.2023.107453
  11. Sunadome H, Murase K, Tabara Y, Matsumoto T, Minami T, Kanai O, Nagasaki T, Takahashi N, Hamada S, Tanizawa K, Togawa J, Uiji S, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Morita S, Takahashi Y, Nakayama T, Hirai T, Sato S, Matsuda F, Chin K. Associations between Sleep-Disordered Breathing and Serum Uric Acid and Their Sex Differences: The Nagahama Study. Nutrients 2023;15(19):4237. doi:10.3390/nu15194237
  12. Morimoto C, Matsumoto H, Nomura N, Sunadome H, Nagasaki T, Sato S, Sato A, Oguma T, Ito I, Kogo M, Tomii K, Tajiri T, Ohashi K, Tsukahara T, Hirai T. Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap. J Allergy Clin Immunol Glob 2024;3(1):100194. doi:10.1016/j.jacig.2023.100194
  13. Kogo M, Sato S, Muro S, Matsumoto H, Nomura N, Oguma T, Sunadome H, Nagasaki T, Murase K, Kawaguchi T, Tabara Y, Matsuda F, Chin K, Hirai T. Longitudinal Changes and Association of Respiratory Symptoms with Preserved Ratio Impaired Spirometry (PRISm): The Nagahama Study. Ann Am Thorac Soc 2023;20(11):1578-1586. doi:10.1513/annalsats.202301-050oc
  14. Maetani T, Tanabe N, Sato A, Shiraishi Y, Sakamoto R, Ogawa E, Sakai H, Matsumoto H, Sato S, Date H, Hirai T, Muro S. Association between blood eosinophil count and small airway eosinophils in smokers with and without chronic obstructive pulmonary disease. ERJ Open Res 2023;9(5):00235-02023. doi:10.1183/23120541.00235-2023
  15. Shimada T, Chubachi S, Otake S, Sakurai K, Sasaki M, Iijima H, Tanabe N, Tanimura K, Shimizu K, Shirahata T, Suzuki M, Sato S, Nakamura H, Asano K, Fukunaga K. Differential impacts between fat mass index and fat-free mass index on patients with COPD. Respir Med 2023;217:107346. doi:10.1016/j.rmed.2023.107346
  16. Hamada S, Togawa J, Sunadome H, Nagasaki T, Takahashi N, Hirai T, Sato S. Sleep restfulness in patients with obstructive sleep apnea receiving continuous positive airway pressure therapy. Sleep Sci 2023; (in press)
  17. Terada S, Tanabe N, Maetani T, Shiraishi Y, Sakamoto R, Shima H, Oguma T, Sato A, Kanasaki M, Masuda I, Sato S, Hirai T. Association of age with computed tomography airway tree morphology in male and female never smokers without lung disease history. Respir Med 2023;214:107278. https://doi.org/10.1016/j.rmed.2023.107278
  18. Tanimura K, Sato S, Fujita Y, Yamamoto Y, Hajiro T, Horita N, Kawayama T, Muro S. The efficacy and safety of additional treatment with short-acting muscarinic antagonist combined with long-acting beta-2 agonist in stable patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. Chron Respir Dis 2023;20:14799731231166008. doi:10.1177/14799731231166008.
  19. Sato S, Oga T, Muro S, Tanimura K, Tanabe N, Nishimura K, Hirai T. Changes in mortality among patients with chronic obstructive pulmonary disease from the 1990s to the 2000s: A pooled analysis of two prospective cohort studies. BMJ Open 2023;13:e065896. doi:10.1136/bmjopen-2022-065896.
  20. Shimizu K, Kimura H, Tanabe N, Chubachi S, Sato S, Suzuki M, Tanimura K, Iijima H, Oguma A, Ito MY, Wakazono N, Takimoto-Sato M, Matsumoto-Sasaki M, Abe Y, Takei N, Makita H, Nishimura M, Konno S. Relationships of Computed Tomography-based Small Vessel Indices of the Lungs with Ventilation Heterogeneity and High Transfer Coefficients in Non-smokers with Asthma. Front Physiol 2023;14:1137603. https://doi.org/10.3389/fphys.2023.1137603
  21. Shiraishi Y, Tanabe N, Shimizu K, Oguma A, Shima H, Sakamoto R, Yamazaki H, Oguma T, Sato A, Suzuki M, Makita H, Muro S, Nishimura M, Sato S, Konno S, Hirai T. Stronger associations of centrilobular than paraseptal emphysema with longitudinal changes in diffusing capacity and mortality in COPD. Chest 2023;164(2):327-338. doi:10.1016/j.chest.2023.01.034
  22. Maetani T, Tanabe N, Shiraishi Y, Shimada Tm Terada S, Shima H, Mochizuki F, Sakamoto R, Kaji S, Oguma T, Sato S, Iijima H, Masuda I, Hirai T. Centrilobular emphysema is associated with pectoralis muscle reduction in current smokers without airflow limitation. Respiration 2023;102:194–202. doi:10.1159/000529031.
  23. Ogawa M, Uchiumi A, Sato S, Hamakawa Y, Kobashi M, Aoyama T, Tanimukai H. Preliminary Study of Assessing Cognitive Impairment in Older Patients with Chronic Obstructive Pulmonary Disease by Using a Cognitive Functional Assessment Tool via a Touchscreen Personal Computer. Multidiscip Respir Med 2023;18:892. https://doi.org/10.4081/mrm.2023.892
  24. Sato S, Miyazaki S, Tamaki A, Yoshimura Y, Arai H, Fujiwara D, Katsura H, Kawagoshi A, Kozu R, Maeda K, Ogawa S, Ueki J, Wakabayashi H. Respiratory sarcopenia: A position paper by four professional organizations. Geriatr Gerontol Int 2023;23(1):5-15. https://doi.org/10.1111/ggi.14519
  25. Maetani T, Tanabe N, Terada S, Shiraishi Y, Shima H, Kaji S, Sakamoto R, Oguma T, Sato S, Masuda I, Hirai T. Physiological impacts of computed tomography airway dysanapsis, fractal dimension and branch count in asymptomatic never smokers. J Appl Physiol 2023;134:20–27. doi: 10.1152/japplphysiol.00385.2022.
  26. Hamada S, Togawa J, Sunadome H, Nagasaki T, Hirai T, Sato S. The Effects of Changing Continuous Positive Airway Pressure Devices in Japanese Patients with Obstructive Sleep Apnea: A Case Series. Internal Med 2023;62(14):2037-2041. doi:10.2169/internalmedicine.0403-22.
  27. Matsumoto T, Murase K, Tabara Y, Minami T, Kanai O, Takeyama H, Sunadome H, Nagasaki T, Takahashi N, Nakatsuka Y, Hamada S, Handa T, Tanizawa K, Nakamoto I, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Morita S, Takahashi Y, Nakayama T, Sato S, Hirai T, Matsuda F, Chin K. Sleep disordered breathing and hemoglobin A1c levels within or over normal range and aging or sex differences; the Nagahama Study. J Sleep Res 2023;32:e13795. doi: 10.1111/jsr.13795
  28. Oguma A, Shimizu K, Kimura H, Tanabe N, Sato S, Yokota I, Sato M, Abe Y, Takei N, Matsumoto-Sasaki M, Goudarzi H, Suzuki M, Makita H, Hirai T, Nishimura M, Konno S. Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation. Allergol Int 2023;72:262–270. https://doi.org/10.1016/j.alit.2022.10.007
  29. Hamada R, Sato S, Miyasaka J, Murao M, Masushita M, Tajimoto T, Otagaki A, Asano T, Nangaku M, Kondo T, Arai Y, Kanda J, Takanori-Kondo A, Ikeguchi R, Matsuda S. Belt electrode-skeletal muscle electrical stimulation during early hematopoietic post-transplantation to prevent skeletal muscle atrophy and weakness. Transplant Cell Ther 2023;29(1):51.e1-51.e7. doi.org/10.1016/j.jtct.2022.09.030
  30. Shima H, Tanabe N, Oguma A, Shimizu K, Kaji S, Terada K, Oguma T, Kubo T, Suzuki M, Makita H, Sato A, Nishimura M, Sato S, Konno S, Hirai T. Subtyping emphysematous COPD by respiratory volume change distributions on computed tomography. Thorax 2023;78:344–353. doi:10.1136/thoraxjnl-2021-218288

  2022年度

  1. Nomura N, Matsumoto H, Yokoyama A, Nishimura Y, Asano K, Niimi A, Tohda Y, Harada N, Nagase H, Nagata M, Inoue H, Kondo M, Horiguchi T, Miyahara N, Hizawa N, Hojo M, Hattori N, Hashimoto N, Yamasaki A, Kadowaki T, Kimura T, Miki M, Taniguchi H, Toyoshima M, Kawamura T, Matsuno O, Sato Y, Sunadome H, Nagasaki T, Oguma T, Hirai T; BEXAS study. Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes. Respir Res 2022;23(1):365. doi: 10.1186/s12931-022-02289-y.
  2. Nagasaki T, Tabuchi T, Matsumoto H, Horimukai K. Age-specific associations of early daycare, older siblings, severe airway infection, and preterm birth with subsequent atopic diseases. Pediatr Allergy Immunol 2022;33(4):e13771. doi: 10.1111/pai.13771.
  3. Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation. J Clin Invest 2022;132(1):e151685. doi: 10.1172/JCI151685.
  4. Tajiri T, Matsumoto H, Jinnai M, Kanemitsu Y, Nagasaki T, Iwata T, Inoue H, Nakaji H, Oguma T, Ito I, Niimi A. Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma. Allergol Int 2022;71(2):193-199. doi: 10.1016/j.alit.2021.09.003.
  5. Togawa J, Matsumoto R, Usami K, Matsuhashi M, Inouchi M, Kobayashi K, Hitomi T, Nakae T, Shimotake A, Yamao Y, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A. Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep. Cereb Cortex 2022;33(2):486-496. doi: 10.1093/cercor/bhac079.
  6. Sakamoto M, Matsumoto R, Shimotake A, Togawa J, Takeyama H, Kobayashi K, Leypoldt F, Wandinger KP, Kondo T, Takahashi R, Ikeda A. Diagnostic value of an algorithm for autoimmune epilepsy in a retrospective cohort. Front Neurol 2022;13:902157.
  7. Nakatani M, Inouchi M, Daifu-Kobayashi M, Murai T, Togawa J, Kajikawa S, Kobayashi K, Hitomi T, Kunieda T, Hashimoto S, Inaji M, Shirozu H, Kanazawa K, Iwasaki M, Usui N, Inoue Y, Maehara T, Ikeda A. Ictal direct current shifts contribute to defining the core ictal focus in epilepsy surgery. Brain Commun 2022;4(5):fcac222. https://doi.org/10.1093/braincomms/fcac222
  8. Ogawa M, Uchiumi A, Sato S, Hamakawa Y, Kobashi M, Aoyama T, Tanimukai H. Preliminary Study of Assessing Cognitive Impairment in Older Patients with Chronic Obstructive Pulmonary Disease by Using a Cognitive Functional Assessment Tool via a Touchscreen Personal Computer. Multidiscip Respir Med. 2022; (in press)
  9. Hamada S, Togawa J, Sunadome H, Nagasaki T, Hirai T, Sato S. The Effects of Changing Continuous Positive Airway Pressure Devices in Japanese Patients with Obstructive Sleep Apnea: A Case Series. Internal Med 2022;0403–22. doi:10.2169/internalmedicine.0403-22.
  10. Sato S, Miyazaki S, Tamaki A, Yoshimura Y, Arai H, Fujiwara D, Katsura H, Kawagoshi A, Kozu R, Maeda K, Ogawa S, Ueki J, Wakabayashi H. Respiratory sarcopenia: A position paper by four professional organizations. Geriatr Gerontol Int 2022; (in press) https://doi.org/10.1111/ggi.14519
  11. Kogo M, Sato S, Muro S, Matsumoto H, Nomura N, Tashima N, Oguma T, Sunadome H, Nagasaki T, Murase K, Kawaguchi T, Tabara Y, Matsuda F, Chin K, Hirai T. Development of airflow limitation, dyspnoea, and both in the general population: The Nagahama study. Sci Rep 2022;12, 20060. https://doi.org/10.1038/s41598-022-24657-w
  12. Matsumoto T, Murase K, Tabara Y, Minami T, Kanai O, Takeyama H, Sunadome H, Nagasaki T, Takahashi N, Nakatsuka Y, Hamada S, Handa T, Tanizawa K, Nakamoto I, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Morita S, Takahashi Y, Nakayama T, Sato S, Hirai T, Matsuda F, Chin K. Sleep disordered breathing and hemoglobin A1c levels within or over normal range and aging or sex differences; the Nagahama Study. J Sleep Res 2022; Nov 27:e13795. (in press) doi: 10.1111/jsr.13795. Epub ahead of print.
  13. Maetani T, Tanabe N, Terada S, Shiraishi Y, Shima H, Kaji S, Sakamoto R, Oguma T, Sato S, Masuda I, Hirai T. Physiological impacts of computed tomography airway dysanapsis, fractal dimension and branch count in asymptomatic never smokers. J Appl Physiol 2023;134:20–27. doi: 10.1152/japplphysiol.00385.2022.
  14. Mochizuki F, Tanabe N, Iijima H, Shimada T, Shiraishi Y, Maetani T, Yamazaki H, Shimizu K, Suzuki M, Chubachi S, Ishikawa H, Naito T, Masuko H, Sakamoto T, Masuda I, Sato S, Hizawa N, Hirai T. Early Chronic Obstructive Pulmonary Disease: Associations of Two Spirometry Criteria with Clinical Features. Respir Med 2022;204:107011. https://doi.org/10.1016/j.rmed.2022.107011
  15. Oguma A, Shimizu K, Kimura H, Tanabe N, Sato S, Yokota I, Sato M, Abe Y, Takei N, Matsumoto-Sasaki M, Goudarzi H, Suzuki M, Makita H, Hirai T, Nishimura M, Konno S. Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation. Allergol Int 2022; (in press) https://doi.org/10.1016/j.alit.2022.10.007
  16. Hamada R, Sato S, Miyasaka J, Murao M, Masudhita M, Tajimoto T, Otagaki A, Asano T, Nangaku M, Kondo T, Arai Y, Kanda J, Takanori-Kondo A, Ikeguchi R, Matsuda S. Belt electrode-skeletal muscle electrical stimulation during early hematopoietic post-transplantation to prevent skeletal muscle atrophy and weakness. Transplant Cell Ther 2022; (in press) doi.org/10.1016/j.jtct.2022.09.030
  17. Maetani T, Tanabe N, Shiraishi Y, Shimada Tm Terada S, Shima H, Mochizuki F, Sakamoto R, Kaji S, Oguma T, Sato S, Iijima H, Masuda I, Hirai T. Centrilobular emphysema is associated with pectoralis muscle reduction in current smokers without airflow limitation. Respiration 2022; (in press)
  18. Tanabe N, Masuda I, Shiraishi Y, Maetani T, Hamada S, Sato A, Sato S, Hirai T. Clinical relevance of multiple confirmed preserved ratio impaired spirometry in adults. Respir Investig 2022;60:822–830. doi:10.1016/j.resinv.2022.08.006
  19. Yoshioka Y, Oshima Y, Hata K, Sato S, Hamad R, Sato T, Kaido T, Munekage F, Ito T, Ikeguchi R, Uemoto S, Hatano E, Matsuda S. Factors Associated with Early Postoperative Exercise Tolerance after Living-Donor Liver Transplantation. Clin Transplant 2022; 2022;e14800. https://doi.org/10.1111/ctr.14800
  20. Ejima A, Abe S, Shimba A, Sato S, Uehata T, Tani-ichi S, Munakata S, Cui G, Takeuchi O, Hirai T, Kato S, Ikuta K. Androgens alleviate allergic airway inflammation by suppressing cytokine production in Th2 cells. J Immunol 2022;209:1083–1094. https://doi.org/10.4049/jimmunol.2200294
  21. Nagata K, Horie T, Chohnabayashi N, Jinta T, Tsugitomi R, Shiraki A, Tokioka F, Kadowaki T, Watanabe A, Fukui M, Kitajima T, Sato S, Tsuda T, Kishimoto N, Kita H, Mori Y, Nakayama M, Takahashi K, Tsuboi T, Yoshida M, Hataji O, Fuke S, Kagajo M, Nishine H, Kobayashi H, Nakamura H, Okuda M, Tachibana S, Takata S, Osoreda H, Minami K, Nishimura T, Ishida T, Terada J, Takeuchi N, Kohashi Y, Inoue H, Nakagawa Y, Kikuchi T, Tomii K, FLOCOP study investigators Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Trial. Am J Respir Crit Care Med 2022; 206:1326–1335. doi: 10.1164/rccm.202201-0199OC
  22. Shima H, Tanabe N, Oguma A, Shimizu K, Kaji S, Terada K, Oguma T, Kubo T, Suzuki M, Makita H, Sato A, Nishimura M, Sato S, Konno S, Hirai T. Subtyping emphysematous COPD by respiratory volume change distributions on computed tomography. Thorax 2022:thoraxjnl-2021-218288. doi:10.1136/thoraxjnl-2021-218288
  23. Hamakawa Y, Sato S, Tanabe N, Rhee CK, Jung KS, Yoo K-H, Tanimura K, Muro S, Hirai T. Non-respiratory symptom dominance is associated with depression in patients with chronic obstructive pulmonary disease. Respir Med 2022;201:106895. doi:10.1016/j.rmed.2022.106895
  24. Shiraishi Y, Shimada T, Tanabe N, Terada K, Sakamoto R, Maetani T, Shima H, Mochizuki F, Oguma T, Shimizu K, Sato S, Muro S, Hizawa N, Fukui M, Iijima H, Masuda I, Hirai T. The prevalence and physiological impacts of centrilobular and paraseptal emphysema on CT in smokers with Preserved Ratio Impaired Spirometry. ERJ Open Res 2022 Jun 27;8(2):00063-2022. doi: 10.1183/23120541.00063-2022
  25. Koda T, Sakamoto T, Wu S, Okumura S, Taki H, Hamada S, Sato S, Chin K. Comparison of Machine Learning and Non-machine Learning Methods for the Sleep Apnea Detection Using Millimeter-wave Radar. IEICE Com Exp 2022;2022XBL0050. https://doi.org/10.1587/comex.2022XBL0050
  26. Sato T, Sato S, Oshima Y, Yoshioka Y, Hamada R, Nankaku M, Ikeda M, Nakajima D, Chen-Yoshikawa TF, Date H, Matsuda S, Tabira K. Impact of inspiratory muscle strength on exercise capacity after lung transplantation. Physiother Res Int 2022 Jul;27(3):e1951. doi: 10.1002/pri.1951
  27. Hamakawa Y, Tanabe N, Shima H, Terada K, Shiraishi Y, Maetani T, Kubo T, Kozawa S, Koizumi K, Kanezaki M, Shimizu K, Oguma T, Sato A, Sato S, Hirai T. Pulmonary and extrapulmonary computed tomographic features in symptomatic and physically inactive patients with chronic obstructive pulmonary disease. Sci Rep 2022;12:5608. doi: 10.1038/s41598-022-09554-6
  28. Kimura H, Shimizu K, Tanabe N, Makita H, Taniguchi N, Kimura H, Suzuki M, Abe Y, Matsumoto-Sasaki M, Oguma A, Takimoto-Sato M, Takei N, Matsumoto M, Goudarzi H, Sato S, Ono J, Izuhara K, Hirai T, Nishimura M, Konno S. Further evidence for association of YKL-40 with severe asthma airway remodeling. Ann Allergy Asthma Immunol 2022;128:682-688.e5. doi:10.1016/j.anai.2022.03.016
  29. Zhang Y, Tanabe N, Shima H, Shiraishi Y, Oguma T, Sato A, Muro S, Sato S, Hirai T. Physiological impairments on respiratory oscillometry and future exacerbations in chronic obstructive pulmonary disease patients without a history of frequent exacerbations. COPD 2022;19(1):149-157. doi: 10.1080/15412555.2022.2051005.
  30. Fukuyama K, Sugiyama O, Chin K, Sato S, Matsumoto S, Muto M. Identification of Respiratory Sounds Collected from Microphones Embedded in Mobile Phones. Adv Biomed Eng 2022;11:58–67. https://doi.org/10.14326/abe.11.58
  31. Hamada S, Handa T, Tanabe N, Sato S, Tanizawa K, Sato A, Morita S, Chin K, Hirai T. Accuracy of respiratory rate surveillance using a home oxygen monitoring device among patients with interstitial lung disease and chronic obstructive pulmonary disease: Accuracy of home oxygen monitoring devices. Sarcoidosis VDLD 2022; 39: e2022007. doi: 10.36141/svdld.v39i1.12133.
  32. Tanabe N, Kaji S, Shima H, Shiraishi Y, Maetani T, Oguma T, Sato S, Hirai T. Kernel conversion for robust quantitative measurements of archived chest computed tomography using deep learning-based image-to-image translation. Front Artif Intell 2022;4:769557. https://doi.org/10.3389/frai.2021.769557.
  33. Ajimizu H, Ozasa H, Sato S, Funazo T, Sakamori Y, Nomizo T, Kuninaga K, Ogimoto T, Hosoya K, Yamazoe M, Tsuji T, Yoshida H, Itotani R, Ueno K, Kim YH, Muro S, Hirai T. Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer. Sci Rep 2021;11:23677. https://doi.org/10.1038/s41598-021-03139-5.
  34. Abe Y, Suzuki M, Shima H, Shiraishi Y, Tanabe N, Sato S, Shimizu K, Kimura H, Makita H, Hirai T, Konno S, Nishimura M. Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis 2021;16:3243-3253. doi:10.2147/copd.s338908
  35. Ibaraki T, Tomoda K, Fujioka N, Sakaguchi K, Fujita Y, Yamamoto Y, Hontsu S, Yamauchi M, Yoshikawa M, Tanabe N, Tanimura K, Sato S, Saeki K, Muro S. Fractal dimension in CT low attenuation areas is predictive of long-term oxygen therapy initiation in COPD patients: Results from two observational cohort studies. Respir Investig 2022;60(1):137–145. doi:10.1016/j.resinv.2021.09.001.
  36. Hamada R, Oshima Y, Sato S, Yoshioka Y, Nankaku M, Kondo T, Chen-Yoshikawa TF, Ikeguchi R, Nakajima D, Date H, Matsuda S. Changes in the health-related quality of life and social reintegration status after lung transplantation following hematopoietic stem cell transplantation. Support Care Cancer 2022;30:1831–1839. doi:10.1007/s00520-021-06592-0.
  37. Oshima Y, Sato S, Chen-Yoshikawa TF, Nakajima D, Nankaku M, Date H, Matsuda S. Erector spinae muscle radiographic density is associated with survival after lung transplantation. J Thorac Cardiovasc Surg 2022;164:300-311.e3. doi:10.1016/j.jtcvs.2021.07.039.
  38. Shimizu K, Tanabe N, Oguma A, Kimura H, Suzuki M, Yokota I, Makita H, Sato S, Hirai T, Nishimura M, Konno S, The Hi-CARAT investigators. Parenchymal destruction in asthma: Fixed airflow obstruction and lung function trajectory. J Allergy Clin Immun 2022;149(3):934-942.e8. doi: 10.1016/j.jaci.2021.07.042.
  39. Takahashi N, Matsumoto T, Nakatsuka Y, Murase K, Tabara Y, Takeyama H, Minami T, Hamada S, Kanai O, Tanizawa K, Nakamoto I, Kawaguchi T, Setoh K, Tsutsumi T, Takahashi Y, Handa T, Wakamura T, Komenami N, Morita S, Hirai T, Matsuda F, Nakayama T, Chin K; Nagahama Study Group. Differences between subjective and objective sleep duration according to actual sleep duration and sleep-disordered breathing: the Nagahama Study. J Clin Sleep Med 2022;18(3):851-859. doi: 10.5664/jcsm.9732.
  40. Murase K, Minami T, Hamada S, Gozal D, Takahashi N, Nakatsuka Y, Takeyama H, Tanizawa K, Endo D, Akahoshi T, Moritsuchi Y, Tsuda T, Toyama Y, Ohi M, Tomita Y, Narui K, Matsuyama N, Ohdaira T, Kasai T, Tsuboi T, Gon Y, Yamashiro Y, Ando S, Yoshimine H, Takata Y, Yoshihisa A, Tatsumi K, Momomura S-I, Kuroda T, Morita S, et al. Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea: A Randomized Controlled Trial. Chest 2022; 162: 1373–1383.
  41. Murase K, Matsumoto T, Tabara Y, Ohler A, Gozal D, Minami T, Kanai O, Takeyama H, Takahashi N, Hamada S, Tanizawa K, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Morita S, Takahashi Y, Nakayama T, Yanagita M, Hirai T, Matsuda F, Chin K. Association of Sleep-disordered Breathing and Blood Pressure with Albuminuria: The Nagahama Study. Ann Am Thorac Soc 2022;19:451–461.

  2021年度

  1. Hamada R, Oshima Y, Sato S, Yoshioka Y, Nankaku M, Kondo T, Chen-Yoshikawa TF, Ikeguchi R, Nakajima D, Date H, Matsuda S. Changes in the health-related quality of life and social reintegration status after lung transplantation following hematopoietic stem cell transplantation. Support Care Cancer 2022;30:1831–1839.
  2. Oshima Y, Sato S, Chen-Yoshikawa TF, Nakajima D, Nankaku M, Date H, Matsuda S. Erector spinae muscle radiographic density is associated with survival after lung transplantation. J Thorac Cardiovasc Surg 2021;1–48. (Journal Pre-Proof)
  3. Kanezaki M, Terada K, Tanabe N, Shima H, Hamakawa Y, Sato S. Exertional multidimensional dyspnoea predicts exacerbation in stable outpatients with COPD. ERJ Open Res 2021;00150–02021.
  4. Hamada R, Oshima Y, Sato S, Yoshioka Y, Sato T, Nankaku M, Kondo T, Chen-Yoshikawa TF, Ikeguchi R, Nakajima D, Date H, Matsuda S. Physical function after lung transplantation for late-onset noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation. Support Care Cancer 2021;29:5447–5454.
  5. Kanezaki M, Terada K, Tanabe N, Shima H, Hamakawa Y, Sato S. Effects of Sarcopenia on Ventilatory Behavior and the Multidimensional Nature of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc 2021;22:827–833.
  6. Koshiyama S, Tanimura K, Ito K, Funayama S, Hira D, Komase Y, Sato S. Gastroesophageal reflux-like symptoms are associated with hyposalivation and oropharyngeal problems in patients with asthma. Respir Investig 2021;59:114–119.
  7. Nakatsuka Y, Murase K, Matsumoto T, Tabara Y, Nakamoto I, Minami T, Takahashi N, Takeyama H, Kanai O, Hamada S, Tanizawa K, Handa T, Wakamura T, Komenami N, Morita S, Nakayama T, Hirai T, Matsuda F, Chin K. Markers of cardiovascular disease risk in sleep-disordered breathing with or without comorbidities: the Nagahama study. J Clin Sleep Med. 2021 Dec 1;17(12):2467–75.
  8. Takahashi N, Matsumoto T, Nakatsuka Y, Murase K, Tabara Y, Takeyama H, Minami T, Hamada S, Kanai O, Tanizawa K, Nakamoto I, Kawaguchi T, Setoh K, Tsutsumi T, Takahashi Y, Handa T, Wakamura T, Komenami N, Morita S, Hirai T, Matsuda F, Nakayama T, Chin K. Differences between subjective and objective sleep duration according to actual sleep duration and sleep-disordered breathing: the Nagahama Study. J Clin Sleep Med. 2021 Oct 26.
  9. Murase K, Matsumoto T, Tabara Y, Ohler A, Gozal D, Minami T, Kanai O, Takeyama H, Takahashi N, Hamada S, Tanizawa K, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Morita S, Takahashi Y, Nakayama T, Yanagita M, Hirai T, Matsuda F, Chin K. Association of Sleep Disordered Breathing and Blood Pressure with Albuminuria: The Nagahama Study. Ann Am Thorac Soc. 2021 Aug 4.
  10. Tomii K, Terada J, Chin K. Increased usage of the high flow nasal cannula in COVID-19 cases in Japan -from the online questionnaire survey by the Japanese Respiratory Society. Respir Investig. 2021 Jun 20;:1–4.
  11. Ikeda M, Oga T, Chen-Yoshikawa TF, Tokuno J, Oto T, Okawa T, Okada Y, Akiba M, Tanaka S, Yamada Y, Yutaka Y, Ohsumi A, Nakajima D, Hamaji M, Isomi M, Chin K, Date H. Patient-reported dyspnea and health predict waitlist mortality in patients waiting for lung transplantation in Japan. Respir Res. 2021 Apr 21;22(1):116–8.
  12. Minami T, Matsumoto T, Tabara Y, Gozal D, Smith D, Murase K, Tanizawa K, Takahashi N, Nakatsuka Y, Hamada S, Handa T, Takeyama H, Oga T, Nakamoto I, Wakamura T, Komenami N, Setoh K, Tsutsumi T, Kawaguchi T, Kamatani Y, Takahashi Y, Morita S, Nakayama T, Hirai T, Matsuda F, Chin K, Nagahama Study Group. Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study. J Clin Sleep Med. 2021 Feb 1;17(2):129–40.
  13. Chin K. Might CPAP prevent exacerbation in patients with COVID-19 with or without obstructive sleep apnea? Sleep Biol Rhythms. 2021 Jan 2;19(1):1–2.
  14. Hamada S, Tabara Y, Murase K, Matsumoto T, Setoh K, Wakamura T, Kawaguchi T, Kosugi S, Nakayama T, Hirai T, Matsuda F, Chin K, Nagahama Study Group. Night-time frequency of urination as a manifestation of sleep-disordered breathing: the Nagahama study. Sleep Med. 2021 Jan;77:288–94.
  15. Inada T, Kobayashi K, Kikuchi T, Matsuhashi M, Matsumoto R, Takahashi Y, Nakae T, Shibata S, Yamao Y, Daifu M, Togawa J, Yoshida K, Kunieda T, Kobayashi K, Ikeda A, Miyamoto S. Effects of a stable concentration of propofol on interictal high-frequency oscillations in drug-resistant epilepsy. Epileptic Disord. 2021 Apr 1;23(2):299-312.
  16. Morimoto C, Matsumoto H, Tajiri T, Gon Y, Ito R, Hashimoto S, Suzukawa M, Ohta K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Kanemitsu Y, Nagasaki T, Izuhara Y, Niimi A, Hirai T. High serum free IL-18 is associated with decreased omalizumab efficacy: findings from a 2-year omalizumab treatment study. J Asthma. 2021 Sep;58(9):1133–42.
  17. Tajiri T, Matsumoto H, Jinnai M, Kanemitsu Y, Nagasaki T, Iwata T, Inoue H, Nakaji H, Oguma T, Ito I, Niimi A. Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma. Allergol Int. 2021 Oct 13.
  18. Sunadome H, Matsumoto H, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Iwanaga T, Hozawa S, Niimi A, Kanemitsu Y, Nagasaki T, Tashima N, Ishiyama Y, Morimoto C, Oguma T, Tajiri T, Ito I, Ono J, Ohta S, Izuhara K, Hirai T. Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort. Allergol Int. 2021 Apr;70(2):252–4.

  2020年度

  1. Minami T, Matsumoto T, Tabara Y, Gozal D, Smith D, Murase K, Tanizawa K, Takahashi N, Nakatsuka Y, Hamada S, Handa T, Takeyama H, Oga T, Nakamoto I, Wakamura T, Komenami N, Setoh K, Tsutsumi T, Kawaguchi T, Kamatani Y, Takahashi Y, Morita S, Nakayama T, Hirai T, Matsuda F, Chin K; Nagahama Study group. Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study. J Clin Sleep Med 2020 in press.
  2. Nakatsuka Y, Yaku A, Handa T, Vandenbon A, Hikichi Y, Motomura Y, Sato A, Yoshinaga M, Tanizawa K, Watanabe K, Hirai T, Chin K, Suzuki Y, Uehata T, Mino T, Tsujimura T, Moro K, Takeuchi O. Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1. Eur Respir J 2020 in press.
  3. Tabara Y, Matsumoto T, Murase K, Setoh K, Kawaguchi T, Kosugi S, Nakayama T, Hirai T, Wakamura T, Chin K, Matsuda F; Nagahama study group. Home device-monitored sleep blood pressure reflects large artery stiffness: the Nagahama study. J Hypertens 2020 in press.
  4. Murase K, Azuma M, Tachikawa R, Minami T, Matsumoto T, Hamada S, Nakatsuka Y, Takahashi N, Takeyama H, Tanizawa K, Oga T, Handa T, Hirai T, Chin K. Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level. Sleep Breath 2020 in press.
  5. Christopher N Schmickl, Shane A Landry, Jeremy E Orr, Kazuo Chin, Kimihiko Murase, Johan Verbraecken, Shahrokh Javaheri, Bradley A Edwards, Robert L Owens , Atul Malhotra. Acetazolamide for OSA and Central Sleep Apnea: A Comprehensive Systematic Review and Meta-Analysis. Chest 2020 in press.
  6. Hamada S, Tabara Y, Murase K, Matsumoto T, Setoh K, Wakamura T, Kawaguchi T, Kosugi S, Nakayama T, Hirai T, Matsuda F, Chin K; Nagahama Study Group. Night-time frequency of urination as a manifestation of sleep-disordered breathing: the Nagahama study. Sleep Med 2020; 77:288-294.
  7. Sunadome H, Matsumoto H, Tachikawa R, Matsumoto T, Tanizawa K, Oga T, Ono J, Ohta S, Izuhara K, Hirai T, Chin K. Role of serum periostin in severe obstructive sleep apnea with albuminuria: an observational study. Respir Res 2020; 21:143
  8. Matsumoto T, Murase K, Tabara Y, Minami T, Kanai O, Takeyama H, Takahashi N, Hamada S, Tanizawa K, Wakamura T, Komenami N, Setoh K, Kawaguchi T, Tsutsumi T, Morita S, Takahashi Y, Nakayama T, Hirai T, Matsuda F, Kazuo Chin K. Sleep disordered breathing and metabolic comorbidities across gender and menopausal status in East Asians; the Nagahama Study. Eur Respir J 2020; 56:1902251.
  9. Nakatsuka Y, Chen-Yoshikawa T, Kinoshita H, Aoyama A, Kubo H, Murase K, Hamada S, Takeyama H, Minami T, Takahashi N, Tanizawa K, Handa T, Hirai T, Date H, Chin K. Nocturnal hypercapnia with daytime normocapnia in patients with advanced pulmonary arterial hypertension awaiting lung transplantation. PLoS One 2020; 15:e0227775
  10. Takahashi N, Takahashi Y, Tabara Y, Matsumoto T, Kawaguchi T, Kuriyama A, Ueshima K, Matsuda F, Chin K, Nakayama T; Nagahama Study Group. Correlates of autonomic nervous system function in a general population with special reference to HbA1c: The Nagahama study. Diabetes Res Clin Pract 2020; 163:108126.
  11. Murase K, Tanizawa K, Minami T, Matsumoto T, Tachikawa R, Takahashi N, Tsuda T, Toyama Y, Ohi M, Akahoshi T, Tomita Y, Narui K, Nakamura H, Ohdaira T, Yoshimine H, Tsuboi T, Yamashiro Y, Ando S, Kasai T, Kita H, Tatsumi K, Burioka N, Tomii K, Kondoh Y, Takeyama H, Handa T, Hamada S, Oga T, Nakayama T, Sakamaki T, Morita S, Kuroda T, Hirai T, Chin K. A Randomized Controlled Trial of Telemedicine for Long-Term Sleep Apnea Continuous Positive Airway Pressure Management. Ann Am Thorac Soc 2020; 17:329-337.