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間質性肺疾患[業績]

呼吸不全・睡眠呼吸障害　｜　間質性肺疾患　｜　COPD　｜　喘息・慢性咳嗽　｜　感染症　｜　肺がん　｜　iPS
  • 2023年度
    1. Nagata S, Ohsumi A, Handa T, Yamada Y, Tanaka S, Yutaka Y, Nakajima D, Tanizawa K, Hirai T, Date H. Assessment of listing criteria for lung transplant candidates with interstitial lung disease. Gen Thorac Cardiovasc Surg 71(1):20-26. 2023.
    2. Oda M, Yamaura K, Ishii H, Kitamura N, Tazawa R, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Tode N, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Tanaka T, Takada T, Nonaka H, Nakata K. Quantitative Evaluation of Changes in Three-Dimensional CT Density Distributions in Pulmonary Alveolar Proteinosis after GM-CSF Inhalation. Respiration 102(2):101-109. 2023. 
    3. Tanaka S, Nakajima D, Sakamoto R, Oguma T, Kawaguchi A, Ohsumi A, Ohata K, Ueda S, Yamagishi H, Kayawake H, Yutaka Y, Yamada Y, Hamaji M, Hamada S, Tanizawa K, Handa T, Suga T, Baba S, Hiramatsu H, Ikeda T, Date H. Outcome and growth of lobar graft after pediatric living-donor lobar lung transplantation. J Heart Lung Transplant 42(5):660-668. 2023. 
    4. Nishioka Y, Homma S, Ogura T, Sato S, Arai N, Tomii K, Kamio K, Sakamoto S, Miyazaki Y, Tomioka H, Hisata S, Handa T, Azuma A. Exploratory phase 2 study of the novel oral multi-kinase inhibitor TAS-115 in patients with idiopathic pulmonary fibrosis. Respir Investig 61(4):498-507. 2023. 
    5. Ichikado K, Ichiyasu H, Iyonaga K, Kawamura K, Higashi N, Johkoh T, Fujimoto K, Morinaga J, Yoshida M, Mitsuzaki K, Suga M, Tanabe N, Handa T, Hirai T, Sakagami T. An observational cohort study of interstitial lung abnormalities (ILAs) in a large Japanese health screening population (Kumamoto ILA study in Japan: KILA-J). BMC Pulm Med 23(1):199. 2023.
    6. Nakayama Y, Nakashima R, Handa T, Ohsumi A, Yamada Y, Nakajima D, Yutaka Y, Tanaka S, Hamada S, Ikezoe K, Tanizawa K, Shirakashi M, Hiwa R, Tsuji H, Kitagori K, Akizuki S, Yoshifuji H, Date H, Morinobu A. Prognosis of patients with systemic sclerosis-related interstitial lung disease on the lung transplant waiting list: a retrospective study. Sci Rep 13(1):10150. 2023. 
    7. Handa T, Matsui S, Yamamoto H, Waseda Y, Iwasawa T, Johkoh T, Notohara K, Hebisawa A. The 2022 revised diagnostic criteria for IgG4-related respiratory diseases. Respir Investig 61(6):755-759. 2023. 
    8. Sato R, Handa T, Tanizawa K, Hirai T. Variation in information needs of patients with interstitial lung disease and their family caregivers according to long-term oxygen therapy: a descriptive study. BMC Pulm Med 23(1):486. 2023.
    9. Okamoto M, Fujimoto K, Johkoh T, Kawaguchi A, Mukae H, Sakamoto N, Ogura T, Ikeda S, Kondoh Y, Yamano Y, Komiya K, Umeki K, Nishikiori H, Tanino Y, Tsuda T, Arai N, Komatsu M, Sakamoto S, Yatera K, Inoue Y, Miyazaki Y, Hashimoto S, Shimizu Y, Hozumi H, Ohnishi H, Handa T, Hattori N, Kishaba T, Kato M, Inomata M, Ishii H, Hamada N, Konno S, Zaizen Y, Azuma A, Suda T, Izuhara K, Hoshino T. A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib. Sci Rep 13(1):22977. 2023.
    10. Nishimura N, Niwamoto T, Arai Y, Nakashima R, Terada K, Yoshizawa A, Sakamoto R, Tanizawa K, Handa T, Morinobu A, Hirai T. Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in a patient with anti-melanoma differentiation-associated gene 5-positive dermatomyositis: A case report and systematic literature review. Int J Rheum Dis 26(6):1172-1177. 2023. 
    11. Misaki Y, Hayashi Y, Shirata M, Terada K, Yoshizawa A, Sakamoto R, Ikezoe K, Tanizawa K, Handa T, Hirai T. Resolution of Eosinophilic Pneumonia after Coronavirus Disease 2019 without Systemic Corticosteroids. Intern Med 62(21):3223-3230. 2023.
    12. Handa T. The potential role of artificial intelligence in the clinical practice of interstitial lung disease. Respir Investig 61(6):702-710. 2023. 
    2022年度
    1. Handa T, Tanizawa K, Oguma T, Uozumi R, Watanabe K, Tanabe N, Niwamoto T, Shima H, Mori R, Nobashi TW, Sakamoto R, Kubo T, Kurosaki A, Kishi K, Nakamoto Y, Hirai TNovel Artificial Intelligence-based Technology for Chest Computed Tomography Analysis of Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2022;19(3):399-406. 
    2. Ikegami N, Nakajima N, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Tanizawa K, Ohsumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chin K, Date H, Hirai T. Clinical, radiological, and pathological features of idiopathic and secondary interstitial pneumonia cases with pleuroparenchymal fibroelastosis undergoing lung transplantation. Histopathology. 2022;80(4):665-676. 
    3. Yamazaki K, Minatoya K, Kumagai M, Handa T, Ohsumi A, Torishima M, Kawasaki H. Valve-sparing Aortic Root Replacement for a Patient With Filamin A Mutation. Ann Thorac Surg. 2022;113(5):e397. 
    4. Hamada S, Handa T, Tanaka S, Date H, Hirai T. Long-term clinical course of patients with pleuroparenchymal fibroelastosis treated with noninvasive positive pressure ventilation. Respir Med Res. 2022;81:100906.
    5. Tanizawa K, Handa T, Nagai S, Yokomatsu T, Ueda S, Ikezoe K, Ogino S, Hirai T, Izumi T. Basal interventricular septum thinning and long-term left ventricular function in patients with sarcoidosis. Respir Investig. 2022;60(3):385-392.
    6. Tanizawa K, Handa T, Nagai S, Ikezoe K, Kubo T, Yokomatsu T, Ueda S, Fushimi Y, Ogino S, Watanabe K, Nakatsuka Y, Hirai T, Izumi T. Lung function decline in sarcoidosis. Respir Investig. 2022;60(4):551-561. 
    7. Hamada S, Handa T, Tanabe N, Sato S, Tanizawa K, Sato A, Morita S, Chin K, Hirai T. Evaluation of respiratory rate monitoring performance using a home oxygen monitoring device among patients with interstitial lung disease and chronic obstructive pulmonary disease. Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(1):e2022007. 
    8. Nagata S, Ohsumi A, Handa T, Yamada Y, Tanaka S, Yutaka Y, Nakajima D, Tanizawa K, Hirai T, Date H. Assessment of listing criteria for lung transplant candidates with interstitial lung disease. Gen Thorac Cardiovasc Surg. 2023;71(1):20-26. 
    9. Komatsu M, Yamamoto H, Matsui S, Terasaki Y, Hebisawa A, Iwasawa T, Johkoh T, Baba T, Miyamoto A, Handa T, Tomii K, Waseda Y, Bando M, Ishii H, Miyazaki Y, Yoshizawa A, Takemura T, Kawabata Y, Hanaoka M, Ogura T; Tokyo Diffuse Lung Disease Study Group. Respiratory lesions in IgG4-related disease: classification using 2019 American College of Rheumatology/European League Against Rheumatism criteria. ERJ Open Res. 2022;8(3):00120-2022. 
    10. Nishioka Y, Toyoda Y, Egashira R, Johkoh T, Terasaki Y, Hebisawa A, Abe K, Baba T, Fujikura Y, Fujita E, Hamada N, Handa T, Hasegawa Y, Hidaka K, Hisada T, Hisata S, Honjo C, Ichikado K, Inoue Y, Izumi S, Kato M, Kishimoto T, Okamoto M, Miki K, Mineshita M, Nakamura Y, Sakamoto S, Sano M, Tsukada Y, Yamasue M, Bando Y, Homma S, Hagiwara K, Suda T, Inase N. Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype. BMJ Open Respir Res. 2022;9(1):e001337.
    11. Oda M, Yamaura K, Ishii H, Kitamura N, Tazawa R, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Tode N, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Tanaka T, Takada T, Nonaka H, Nakata K. Quantitative Evaluation of Changes in Three-Dimensional CT Density Distributions in Pulmonary Alveolar Proteinosis after GM-CSF Inhalation. Respiration. 2023;102(2):101-109. 
    12. Tanaka S, Nakajima D, Sakamoto R, Oguma T, Kawaguchi A, Ohsumi A, Ohata K, Ueda S, Yamagishi H, Kayawake H, Yutaka Y, Yamada Y, Hamaji M, Hamada S, Tanizawa K, Handa T, Suga T, Baba S, Hiramatsu H, Ikeda T, Date H. Outcome and growth of lobar graft after pediatric living-donor lobar lung transplantation. J Heart Lung Transplant. 2022;S1053-2498(22)02255-0.
    2021年度
    1. Tanabe N, Kumamaru H, Tamura Y, Taniguchi H, Emoto N, Yamada Y, Nishiyama O, Tsujino I, Kuraishi H, Nishimura Y, Kimura H, Inoue Y, Morio Y, Nakatsumi Y, Satoh T, Hanaoka M, Kusaka K, Sumitani M, Handa T, Sakao S, Kimura T, Kondoh Y, Nakayama K, Tanaka K, Ohira H, Nishimura M, Miyata H, Tatsumi K; JRPHS Group. Multi-Institutional Prospective Cohort Study of Patients With Pulmonary Hypertension Associated With Respiratory Diseases. Circ J. 85(4):333-342. 2021.

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    2. Shiiya H, Nakajima J, Date H, Chen-Yoshikawa TF, Tanizawa K, Handa T, Oto T, Otani S, Shiotani T, Okada Y, Matsuda Y, Shiraishi T, Moroga T, Minami M, Funaki S, Chida M, Yoshino I, Hatachi G, Uemura Y, Sato M. Outcomes of lung transplantation for idiopathic pleuroparenchymal fibroelastosis. Surg Today. 51(8):1276-1284. 2021
    3. Sakaue S, Yamaguchi E, Inoue Y, Takahashi M, Hirata J, Suzuki K, Ito S, Arai T, Hirose M, Tanino Y, Nikaido T, Ichiwata T, Ohkouchi S, Hirano T, Takada T, Miyawaki S, Dofuku S, Maeda Y, Nii T, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Sonehara K, Tazawa R, Morimoto K, Takaki M, Konno S, Suzuki M, Tomii K, Nakagawa A, Handa T, Tanizawa K, Ishii H, Ishida M, Kato T, Takeda N, Yokomura K, Matsui T, Watanabe M, Inoue H, Imaizumi K, Goto Y, Kida H, Fujisawa T, Suda T, Yamada T, Satake Y, Ibata H, Hizawa N, Mochizuki H, Kumanogoh A, Matsuda F, Nakata K, Hirota T, Tamari M, Okada Y. Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis. Nat Commun. 12(1):1032. 2021.
    4. Ohsumi A, Nakajima D, Yoshizawa A, Yamanashi K, Nagata S, Tanizawa K, Handa T, Date H. Living-Donor Lung Transplantation for Dyskeratosis Congenita. Ann Thorac Surg. 112(6):e397-e402. 2021.
    5. Hamada S, Handa T, Hirai T. Evaluation of Respiratory Mechanics With Dynamic Breathing Magnetic Resonance Imaging in Pleuroparenchymal Fibroelastosis: Limited Lower Chest Wall Motion and Preserved Diaphragm Motion. Arch Bronconeumol (Engl Ed). in press.
    6. Tanabe N, Kaji S, Sato S, Yokoyama T, Oguma T, Tanizawa K, Handa T, Sakajo T, Hirai T. A homological approach to a mathematical definition of pulmonary fibrosis and emphysema on computed tomography. J Appl Physiol (1985). 131(2):601-612. 2021. 
    7. Niwamoto T, Handa T, Murase Y, Nakatsuka Y, Tanizawa K, Taguchi Y, Tomioka H, Tomii K, Kita H, Uyama M, Tsuchiya M, Emura M, Kawamura T, Arai N, Arita M, Uno K, Yoshizawa A, Uozumi R, Yamaguchi I, Matsuda F, Chin K, Hirai T. Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study. Respir Res. 22(1):181. 2021.
    8. Handa T, Tanizawa K, Oguma T, Uozumi R, Watanabe K, Tanabe N, Niwamoto T, Shima H, Mori R, Nobashi TW, Sakamoto R, Kubo T, Kurosaki A, Kishi K, Nakamoto Y, Hirai T. Novel Artificial Intelligence-based Technology for Chest Computed Tomography Analysis of Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. in press. 
    9. Komatsu M, Yamamoto H, Matsui S, Terasaki Y, Hebisawa A, Iwasawa T, Johkoh T, Baba T, Miyamoto A, Handa T, Tomii K, Waseda Y, Bando M, Ishii H, Miyazaki Y, Yoshizawa A, Takemura T, Kawabata Y, Ogura T. Clinical characteristics of immunoglobulin G4-positive interstitial pneumonia. ERJ Open Res. 7(3):00317-2021. 2021
    10. Ikegami N, Nakajima N, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Tanizawa K, Ohsumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chin K, Date H, Hirai T. 
Clinical, radiological, and pathological features of idiopathic and secondary interstitial pneumonia cases with pleuroparenchymal fibroelastosis undergoing lung transplantation. Histopathology. in press. 
    11. Sato R, Handa T, Matsumoto H, Hirai K, Ohkura N, Kubo T, Hirai T. Antitussive Effect of a Chest Band in Patients with Interstitial Lung Disease: The Preliminary Results from a Pre-post Intervention Study. Intern Med. 60(23):3701-3707. 2021. 
    2020年度
    1. Nakata K, Sugi T, Kuroda K, Yoshizawa K, Takada T, Tazawa R, Ueda T, Aoki A, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Oda M, Ishii H, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Hirano T, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Sakagami T, Tanaka T, Mikami A, Kitamura N:Validation of a New Serum Granulocyte-Macrophage Colony-Stimulating Factor Autoantibody Testing Kit. ERJ Open Res 6(1). 00259-2019. 2020.
    2. Shirakashi M, Nakashima R, Tsuji H, Tanizawa K, Handa T, Hosono Y, Akizuki S, Murakami K, Hashimoto M, Yoshifuji H, Ohmura K, Mimori T:Efficacy of plasma exchange in anti-MDA5-positive dermatomyositis with interstitial lung disease under combined immunosuppressive treatment. Rheumatology (Oxford) 59 (11). 3284-3292. 2020.
    3. Nakanishi T, Forgetta V, Handa T, Hirai T, Mooser V, Lathrop GM, Cookson WOCM, Richards JB:The undiagnosed disease burden associated with alpha-1 antitrypsin deficiency genotypes. Eur Respir J 56(6). 2001441. 2020. 
    4. Nakatsuka Y, Yaku A, Handa T, Vandenbon A, Hikichi Y, Motomura Y, Sato A, Yoshinaga M, Tanizawa K, Watanabe K, Hirai T, Chin K, Suzuki Y, Uehata T, Mino T, Tsujimura T, Moro K, Takeuchi O. Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1. Eur Respir J 2000018. 2020. 
    2019年
    1. Nakatsuka Y, Handa T, Nakashima R, Tanizawa K, Kubo T, Murase Y, Sokai A, Ikezoe K, Hosono Y, Watanabe K, Tokuda S, Uno K, Yoshizawa A, Tsuruyama T, Uozumi R, Nagai S, Hatta K, Taguchi Y, Mishima M, Chin K, Mimori T, Hirai T. Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease. Rheumatology (Oxford). 2019.
    2. Tanizawa K, Handa T, Nagai S, Oga T, Kubo T, Ito Y, Aihara K, Ikezoe K, Sokai A, Nakatsuka Y, Hirai T, Chin K, Mishima M, Izumi T. Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients?　Respir Med. 149. 1-8. 2019.
    3. Tazawa R, Ueda T, Abe M, Tatsumi K, Eda R, Kondoh S, Morimoto K, Tanaka T, Yamaguchi E, Takahashi A, Oda M, Ishii H, Izumi S, Sugiyama H, Nakagawa A, Tomii K, Suzuki M, Konno S, Ohkouchi S, Tode N, Handa T, Hirai T, Inoue Y, Arai T, Asakawa K, Sakagami T, Hashimoto A, Tanaka T, Takada T, Mikami A, Kitamura N, Nakata K. Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.　N Engl J Med. 381(10). 923-932. 2019.
    4. Tsuji H, Nakashima R, Hosono Y, Imura Y, Yagita M, Yoshifuji H, Hirata S, Nojima T, Sugiyama E, Hatta K, Taguchi Y, Katayama M, Tanizawa K, Handa T, Uozumi R, Akizuki S, Murakami K, Hashimoto M, Tanaka M, Ohmura K, Mimori T. A Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy with High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis.　Arthritis Rheumatol. 2019.
    5. Sato R, Handa T, Matsumoto H, Kubo T, Hirai T. Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study.　BMC Pulm Med. 19(1). 247. 2019.
    2018年
    1. Handa T, Matsui S, Yoshifuji H, Kodama Y, Yamamoto H, Minamoto S, Waseda Y, Sato Y, Kubo K, Mimori T, Chiba T, Hirai T, Mishima M.. Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease. Mod Rheumatol 28(5):838-844, 2018
    2. Nakatsuka Y, Vandenbon A, Mino T, Yoshinaga M, Uehata T, Cui X, Sato A, Tsujimura T, Suzuki Y, Sato A, Handa T, Chin K, Sawa T, Hirai T, Takeuchi O. Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Mucosal Immunol 11(4):1203-1218, 2018
    3. Nakatsuka Y, Handa T, Kokosi M, Tanizawa K, Puglisi S, Jacob J, Sokai A, Ikezoe K, Kanatani KT, Kubo T, Tomioka H, Taguchi Y, Nagai S, Chin K, Mishima M, Wells AU, Hirai T. The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients. Respiration 96(4):338-347, 2018
    4. Tanizawa K, Handa T, Kubo T, Chen-Yoshikawa TF, Aoyama A, Motoyama H, Hijiya K, Yoshizawa A, Oshima Y, Ikezoe K, Tokuda S, Nakatsuka Y, Murase Y, Nagai S, Muro S, Oga T, Chin K, Hirai T, Date H. Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study. Respir Res 19 (1):162, 2018
    5. Oga T, Windisch W, Handa T, Hirai T, Chin K. Health-related quality of life measurement in patients with chronic respiratory failure. Respir Investig 56(3):214-221, 2018
    6. Matsuo H, Handa T, Tsuchiya M, Kubo T, Yoshizawa A, Nakayama Y, Shiga S, Hitomi T, Adachi S, Date H, Hirai T, Ichiyama S. Progressive Restrictive Ventilatory Impairment in Idiopathic Diffuse Pulmonary Ossification. Intern Med 57(11):1631-1636, 2018
    2017年
    1. Tanizawa K, Handa T, Nagai S, Niimi A, Oguma T, Kubo T, Ito Y, Aihara K, Ikezoe 　　K, Matsumoto H, Hirai T, Chin K, Mishima M. Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. ERJ Open Res. 3(1). 2017.
    2. Tanizawa K, Handa T, Nakashima R, Kubo T, Hosono Y, Watanabe K, Aihara K, Ikezoe K, Sokai A, Nakatsuka Y, Taguchi Y, Hatta K, Noma S, Kobashi Y, Yoshizawa A, Oga T, Hirai T, Chin K, Nagai S, Izumi T, Mimori T, Mishima M. The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies. Respir Med. 127:57-64. 2017.
    3. Ikezoe K, Handa T, Tanizawa K, Yokoi H, Kubo T, Aihara K, Sokai A, Nakatsuka Y, Hashimoto S, Uemasu K, Sato S, Muro S, Nagai S, Yanagita M, Chin K, Hirai T, Taguchi Y, Mishima M. Chronic Kidney Disease Predicts Survival in Patients with Idiopathic Pulmonary Fibrosis. Respiration. 94:346-354. 2017.
    4. Ikezoe K, Handa T, Tanizawa K, Chen-Yoshikawa TF, Kubo T, Aoyama A, Motoyama H, Hijiya K, Tokuda S, Nakatsuka Y, Yamamoto Y, Oshima A, Harashima SI, Nagai S, Hirai T, Date H, Chin K. Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease. PLoS One. 12(8):e0183171. 2017.
    5. Sokai A, Tanizawa K, Handa T, Kubo T, Hashimoto S, Ikezoe K, Nakatsuka Y, Aihara K, Taguchi Y, Muro S, Oga T, Nagai S, Izumi T, Hirai T, Chin K, Mishima M. Asymmetry in acute exacerbation of idiopathic pulmonary fibrosis. ERJ Open Res. 3(2).
    6. Sokai A, Tanizawa K, Handa T, Kanatani K, Kubo T, Ikezoe K, Nakatsuka Y, Tokuda S, Oga T, Hirai T, Nagai S, Chin K, Mishima M. Importance of serial changes in biomarkers in idiopathic pulmonary fibrosis. ERJ Open Res. 3(3). 2017.
    7. Handa T, Matsui S, Yoshifuji H, Kodama Y, Yamamoto H, Minamoto S, Waseda Y, Sato Y, Kubo K, Mimori T, Chiba T, Hirai T, Mishima M. Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease. Mod Rheumatol. 1-21. 2017.
    8. Tanizawa K, Handa T, Nagai S, Niimi A, Oguma T, Kubo T, Ito Y, Aihara K, Ikezoe K, Matsumoto H, Hirai T, Chin K, Mishima M. Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. ERJ Open Res 3(1). 2017.
    2016年
    1. Sokai A, Handa T, Chen F, Tanizawa K, Aoyama A, Kubo T, Ikezoe K, Nakatsuka Y, Oguma T, Hirai T, Nagai S, Chin K, Date H, Mishima M. Serial perfusion in native lungs in patients with idiopathic pulmonary fibrosis and other interstitial lung diseases after single lung transplantation. Clin Transplant. 30(4):407-14.2016.
    2. Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma. Sci Rep. 6:25781.2016
    3. Nobashi T, Nakamoto Y, Kubo T, Ishimori T, Handa T, Tanizawa K, Sano K, Mishima M, Togashi K. The utility of PET/CT with 68Ga-DOTATOC in sarcoidosis: comparison with Ga67-scintigraphy. Ann Nucl Med. 30(8):544-52.2016.
    4. Nobashi T, Kubo T, Nakamoto Y, Handa T, Koyasu S, Ishimori T, Mishima M, Togashi K. FDG uptake in less affected lung field provides prognostic stratification in patients with interstitial lung disease. J Nucl Med. 57(12):1899-1904. 2016.
    5. Handa T, Watanabe K, Tanizawa K, Oga T, Aihara K, Ikezoe K, Sokai A,　Nakatsuka Y, Hirai T, Nagai S, Chin K, Horiuchi H, Mishima M. Platelet aggregability in patients with interstitial pneumonias. Sarcoidosis Vasc Diffuse Lung Dis. 33(2):143-50. 2016.
    2015年
    1. Nakatsuka Y, Handa T, Nakamoto Y, Nobashi T, Yoshihuji H, Tanizawa K, Ikezoe K, Sokai A, Kubo T, Hirai T, Chin K, Togashi K, Mimori T, Mishima M. Total lesion glycolysis as an IgG4-related disease activity marker. Mod Rheumatol. 25(4): 579-84. 2015.
    2. Ikezoe K, Handa T, Tanizawa K, Kubo T, Ito I, Sokai A, Nakatsuka Y, Nagai S, Izumi T, Mishima M. A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis. Tissue Antigens. 85(3): 204-8. 2015.
    3. Ikezoe K, Handa T, Tanizawa K, Kubo T, Oguma T, Hamada S, Watanabe K, Aihara K, Sokai A, Nakatsuka Y, Muro S, Nagai S, Uno K, Chin K, Fukui M, Hirai T, Mishima M. Bone mineral density in patients with idiopathic pulmonary fibrosis.　Respir Med. 109(9): 1181-7. 2015.
    4. Tanizawa K, Handa T, Nagai S, Hirai T, Kubo T, Oguma T, Ito I, Ito Y, Watanabe K, Aihara K, Ikezoe K, Oga T, Chin K, Izumi T, Mishima M. Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias.　BMC Pulm Med. 15: 74. 2015.
    5. Akasaka K, Tanaka T, Kitamura N, Ohkouchi S, Tazawa R, Takada T, Ichiwata T, Yamaguchi E, Hirose M, Arai T, Nakano K, Nei T, Ishii H, Handa T, Inoue Y, Nakata K. Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study.　BMC Pulm Med. 15: 88. 2015.
    6. Sokai A, Handa T, Tanizawa K, Oga T, Uno K, Tsuruyama T, Kubo T, Ikezoe K, Nakatsuka Y, Tanimura K, Muro S, Hirai T, Nagai S, Chin K, Mishima M. Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis. Respir Res. 16: 120. 2015.
    7. Nakatsuka Y, Handa T, Nakamoto Y, Nobashi T, Yoshihuji H, Tanizawa K, Ikezoe K, Sokai A, Kubo T, Hirai T, Chin K, Togashi K, Mimori T, Mishima M. Total lesion glycolysis as an IgG4-related disease activity marker. Mod Rheumatol. 25(4): 579-84. 2015.
    8. Ikezoe K, Handa T, Tanizawa K, Kubo T, Ito I, Sokai A, Nakatsuka Y, Nagai S, Izumi T, Mishima M. A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis. Tissue Antigens. 85(3): 204-8. 2015.
    9. Ikezoe K, Handa T, Tanizawa K, Kubo T, Oguma T, Hamada S, Watanabe K, Aihara K, Sokai A, Nakatsuka Y, Muro S, Nagai S, Uno K, Chin K, Fukui M, Hirai T, Mishima M. Bone mineral density in patients with idiopathic pulmonary fibrosis.　Respir Med. 109(9): 1181-7. 2015.
    10. Tanizawa K, Handa T, Nagai S, Hirai T, Kubo T, Oguma T, Ito I, Ito Y, Watanabe K, Aihara K, Ikezoe K, Oga T, Chin K, Izumi T, Mishima M. Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias.　BMC Pulm Med. 15: 74. 2015.
    11. Akasaka K, Tanaka T, Kitamura N, Ohkouchi S, Tazawa R, Takada T, Ichiwata T, Yamaguchi E, Hirose M, Arai T, Nakano K, Nei T, Ishii H, Handa T, Inoue Y, Nakata K. Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study.　BMC Pulm Med. 15: 88. 2015.
    12. Sokai A, Handa T, Tanizawa K, Oga T, Uno K, Tsuruyama T, Kubo T, Ikezoe K, Nakatsuka Y, Tanimura K, Muro S, Hirai T, Nagai S, Chin K, Mishima M. Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis. Respir Res. 16: 120. 2015.
    2014年
    1. Sonobe M, Handa T, Tanizawa K, Sato M, Sato T, Chen F, Omasa M, Bando T, Date H, Mishima M. Videothoracoscopy-assisted surgical lung biopsy for interstitial lung diseases.Gen Thorac Cardiovasc Surg. 2014 Mar 13. [Epub ahead of print]
    2. Nagai S, Yokomatsu T, Tanizawa K, Ikezoe K, Handa T, Ito Y, Ogino S, Izumi T.Treatment with Methotrexate and Low-dose Corticosteroids in Sarcoidosis Patients with Cardiac Lesions. Intern Med. 2014; 53:427-433.
    3. Handa T, Nakatsue T, Baba M, Takada T, Nakata K, Ishii H. Clinical features of three cases with pulmonary alveolar proteinosis secondary to myelodysplastic syndrome developed during the course of Behçet’s disease.Respir Investig. 2014; 52:75-79.
    4. Handa T, Okano Y, Nakanishi N, Morisaki T, Morisaki H, Mishima M. BMPR2 gene mutation in pulmonary arteriovenous malformation and pulmonary　hypertension: A case report. Respir Investig. in press.
    2013年
    1. Handa T, Nakatsue T, Baba M, Takada T, Nakata K, Ishii H. Clinical Features of three Cases with Pulmonary Alveolar Proteinosis Secondary to Myelodysplastic Syndrome developed during the course of Behçet’s Disease. Respir Investig 2013 in press.
    2. Aihara K, Handa T, Oga T, Watanabe K, Tanizawa K, Ikezoe K, Taguchi Y, Sato H, Chin K, Nagai S, Narumiya S, Wells AU, Mishima M. Clinical relevance of plasma prostaglandin f2α metabolite concentrations in patients with idiopathic pulmonary fibrosis.　PLoS One. 2013 Jun 11;8(6):e66017.
    3. Tanizawa K, Handa T, Nakashima R, Kubo T, Hosono Y, Aihara K, Ikezoe K, Watanabe K, Taguchi Y, Hatta K, Oga T, Chin K, Nagai S,Mimori T, Mishima M. The prognostic value of HRCT in myositis-associated interstitial lung disease. Respir Med. 2013; 107:745-752.
    4. Tanizawa K, Handa T, Nagai S, Sato H, Yamada R, Ito I, Kubo T, Ito Y, Watanabe K, Aihara K, Ikezoe K, Mishima M, Izumi T. Interferon regulatory factor 5 polymorphisms in sarcoidosis. Mod Rheumatol 2013.
    5. Aihara K, Handa T, Nagai S, Tanizawa K, Ikezoe K, Watanabe K, Chihara Y, Harada Y, Yoshimura C, Oga T, Ozasa N, Uno K, Chin K, Mishima M. Impaired endothelium-dependent vasodilator response in patients with pulmonary fibrosis. Respir Med 2013; 107:269-275.
      2012年
    6. Baughman RP, Drent M, Culver DA, Grutters JC, Handa T, Humbert M, Judson MA, Lower EE, Mana J, Pereira CA, Prasse A, Sulica R,Valyere D, Vucinic V, Wells AU. Endpoints for clinical trials of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2012; 29:90-98.
    7. Hasegawa K, Ohno S, Takada M, Ogino H, Shiotsu S, Takumi C, Hiraoka N, Handa T, Nagai S. Sarcoidosis complicated with major pulmonary artery obstruction and stenosis. Intern Med. 2012; 51:2775-2780.
      2011年
    8. Tanizawa K, Handa T, Nagai S, Ito I, Kubo T, Ito Y, Watanabe K, Aihara K, Mishima M, Izumi T. A CD40 single-nucleotide polymorphism affects the lymphocyte profiles in the bronchoalveolar lavage of Japanese patients with sarcoidosis.　Tissue Antigens 2011; 78:442-445.
    9. Tanizawa K, Handa T, Nakashima R, Kubo T, Hosono Y, Watanabe K, Aihara K, Oga T, Chin K, Nagai S, Mimori T, Mishima M. HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody. Respir Med 2011; 105:1380-1387.
    10. Aihara K, Handa T, Nagai S, Tanizawa K, Watanabe K, Harada Y, Chihara Y, Hitomi T, Oga T, Tsuboi T, Chin K, Mishima M. Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. Intern Med 2011; 50:1157-1162.
    11. Tanizawa K, Handa T, Nagai S, Oga T, Kubo T, Ito Y, Watanabe K, Aihara K, Chin K, Mishima M, Izumi T. Validation of the Japanese version of the Sarcoidosis Health Questionnaire: A cross-sectional study. Health Qual Life Outcomes 2011; 9:34.
    12. Watanabe K, Handa T, Tanizawa K, Hosono Y, Taguchi Y, Noma S, Kobashi Y, Kubo T, Aihara K, Chin K, Nagai S, Mimori T, Mishima M. Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias. Respir Med 2011; 105:1238-1247.
      2010年
    13. Tomii K, Tachikawa R, Chin K, Murase K, Handa T, Mishima M, Ishihara K. Role of non-invasive ventilation in managing life-threatening acute exacerbation of interstitial pneumonia. Intern Med 2010; 49:1341-1347.
    14. Handa T, Nagai S, Ueda S, Chin K, Ito Y, Watanabe K, Tanizawa K, Tamaya M, Mishima M, Izumi T.　Significance of plasma NT-proBNP levels as a biomarker in the assessment of cardiac involvement and pulmonary hypertension in patients with sarcoidosis.　Sarcoidosis Vasc Diffuse Lung Dis 2010; 27:27-35.

      15. a

    15. Tanizawa K, Handa T, Nagai S, Ito Y, Watanabe K, Aihara K, Izumi T, Mishima M.　CD24 gene exon 2 dimorphism does not affect disease susceptibility in Japanese sarcoidosis patients.　Sarcoidosis Vasc Diffuse Lung Dis 2010; 27: 64-69.
      2009年
    16. Handa T, Nagai S, Hirai T, Chin K, Kubo T, Oga T, Niimi A, Matsumoto H, Ito Y, Takahashi K, Watanabe K, Izumi T, Mishima M. Computed tomography analysis of airway dimensions and lung density in patients with sarcoidosis. Respiration 2009; 77:273-281.
    17. Handa T, Nagai S, Kitaichi M, Chin K, Ito Y, Oga T, Takahashi K, Watanabe K, Mishima M, Izumi T Long-term complications and prognosis of chronic beryllium disease. Sarcoidosis Vasc Diffuse Lung Dis 2009; 26:24-31.
      2008年
    18. Nagai S, Handa T, Ito Y, Ohta K, Tamaya M, Izumi T. Outcome of sarcoidosis. Clin Chest Med 2008; 29: 565-574.
    19. Nagai S, Handa T, Kim D. Pharmacotherapy in patients with idiopathic pulmonary fibrosis. Expert Opin Pharmacother 2008; 9: 1909-1925.
      2007年
    20. Nagai S, Handa T, Ito Y, Takeuchi M, Izumi T. Bronchoalveolar lavage in idiopathic interstitial lung diseases.　Semin Respir Crit Care Med 2007; 28: 496-503.
    21. Hamada K, Nagai S, Tanaka S, Handa T, Shigematsu M, Nagao T, Mishima M, Kitaichi M, Izumi T. Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticator in patients with idiopathic pulmonary fibrosis. Chest 2007; 131:650-656.
    22. Handa T, Nagai S, Miki S, Ueda S, Yukawa N, Fushimi Y, Ito Y, Ohta K, Mimori T, Mishima M, Izumi T. Incidence of pulmonary hypertension and its clinical relevance in patients with interstitial pneumonias: comparison between idiopathic and collagen vascular disease associated interstitial pneumonias. Intern Med 2007; 46:831-837.
    23. Sato H, Nagai S, du Bois RM, Handa T, Suginoshita Y, Ohta K, Welsh KI, Izumi T. HLA-DQB1 0602 allele is associated with splenomegaly in Japanese sarcoidosis. J Intern Med 2007; 262:449-457.
      2006年
    24. Handa T, Nagai S, Miki S, Fushimi Y, Ohta K, Mishima M, Izumi T. Incidence of pulmonary hypertension and its clinical relevance in patients with sarcoidosis. Chest 2006; 129:1246-1252.
    25. Handa T, Nagai S, Fushimi Y, Miki S, Ohta K, Niimi A, Mishima M, Izumi T. Clinical and radiographic indices associated with airflow limitation in patients with sarcoidosis. Chest 2006; 130:1851-1856.
      2005年
    26. Handa T, Nagai S, Ito I, Tabuena R, Shigematsu M, Hamada K, Kitaichi M, Izumi T, Aoyama T, Toguchida J, Mishima M. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. Respiration 2005; 72:243-248.
    27. Handa T, Nagai S, Kawabata D, Nagao T, Takemura M, Kitaichi M, Izumi T, Mimori T, Mishima M. Long-term clinical course of a patient with anti PL-12 antibody accompanied by interstitial pneumonia and severe pulmonary hypertension. Intern Med 2005; 44:319-325.
    28. Handa T, Nagai S, Ito I, Shigematsu M, Hamada K, Kitaichi M, Ohta K, Izumi T, Mishima M. Multiple bone fractures found in a young sarcoidosis patient with long stable disease. Intern Med 2005; 44:1269-1275.
    29. Handa T, Nagai S, Shigematsu M, Tabuena RP, Takeuchi M, Mikuniya T, Hamada K, Izumi T, Mishima M. Patient characteristics and clinical features of Japanese sarcoidosis patients with low bronchoalveolar lavage CD4/CD8 ratios. Sarcoidosis Vasc Diffuse Lung Dis 2005; 22:154-160.
    30. Ito I, Nagai S, Handa T, Muro S, Hirai T, Tsukino M, Mishima M. Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema. Am J Respir Crit Care Med 2005; 172: 1378-1382.
    31. Tabuena RP, Nagai S, Tsutsumi T, Handa T, Minoru T, Mikuniya T, Shigematsu M, Hamada K, Izumi T, Mishima M. Cell profiles of bronchoalveolar lavage fluid as prognosticators of idiopathic pulmonary fibrosis/usual interstitial pneumonia among Japanese Patients. Respiration 2005; 72: 490-498.
    32. Ito I, Nagai S, Kitaichi M, Nicholson AG, Johkoh T, Noma S, Kim DS, Handa T, Izumi T, Mishima M. Pulmonary manifestations of primary Sjogren’s syndrome: a clinical, radiologic, and pathologic study. Am J Respir Crit Care Med 2005; 171:632-638.
      2004年
    33. Tabuena RP, Nagai S, Handa T, Shigematsu M, Hamada K, Ito I, Izumi T, Mishima M, Sharma OP. Diabetes insipidus from neurosarcoidosis: long-term follow-up for more than eight years. Intern Med 2004 ; 43: 960-966.
    34. Nagai S, Handa T, Tabuena R, Kitaichi M, Izumi T. Nonspecific interstitial pneumonia: a real clinical entity? Clin Chest Med 2004; 25: 705-715.
      2003年
    35. Handa T, Nagai S, Hamada K, Ito I, Hoshino Y, Shigematsu M, Izumi T, Mishima M. Sarcoidosis with bilateral epididymal and testicular lesions. Intern Med 2003; 42: 92-97.
    36. Handa T, Ono T, Watanabe H, Takeda T, Muso E, Kita T.　Glomerulonephritis induced by methicillin-sensitive Staphylococcus aureus infection.　Clin Exp Nephrol 2003; 7:247-249.
    37. Handa T, Nagai S, Ito I, Shigematsu M, Hamada K, Kitaichi M, Izumi T, Mishima M. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2003; 20: 190-196.
呼吸不全・睡眠呼吸障害　｜　間質性肺疾患　｜　COPD　｜　喘息・慢性咳嗽　｜　感染症　｜　肺がん　｜　iPS