iPS

• 2023年度

  1. Yifei Xu, Guofei Feng, Taichi Yano, Sawako Masuda, Mizuho Nagao, Shimpei Gotoh, Makoto Ikejiri, Masaki Tanabe & Kazuhiko Takeuchi: “Characteristic genetic spectrum of primary ciliary dyskinesia in Japanese patients and global ethnic heterogeneity: population-based genomic variation database analysis.” Journal of Human Genetics. 2023 Mar 2;68(7):455-461.
  2. Yukiko Muramoto, Senye Takahashi, Peter J Halfmann, Shimpei Gotoh, Takeshi Noda, Yoshihiro Kawaoka: “Replicative capacity of SARS-CoV-2 omicron variants BA.5 and BQ.1.1 at elevated temperatures.” The Lancet Microbe. 2023 Apr 24;4(7):E486
  3. Koichiro Kawagichi, Azusa Asai, Ryuta Mikawa, Noboru Ogiso, and Masataka Sugimoto: “Age-related changes in lung function in national center for geriatrics and gerontology aging farm C57BL/6N mice.” Experimental Animals. 2023 May 17;72(2):173–182.
  4. Rongbo Li, Naoyuki Sone (Co-first), Shimpei Gotoh, Xin Sun, James S. Hagood: “Contemporary and emerging technologies for research in children’s rare and interstitial lung disease.” Pediatric Pulmonology. 2023 May 19.
  5. Motoyasu Hosokawa, Ryuta Mikawa, Atsuko Hagiwara, Yukiko Okuno, Tomonari Awaya, Yuki Yamamoto, Senye Takahashi, Haruka Yamaki, Mitsujiro Osawa, Yasuhiro Setoguchi, Megumu K Saito, Shinji Abe, Toyohiro Hirai, Shimpei Gotoh, Masatoshi Hagiwara: “Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC.” iScience. 2023 Aug 25; 26 (10):107731.
  6. Ryo Niwa, Kouji Sakai, Mandy Siu Yu Lung, Tomoko Matsumoto, Ryuta Mikawa, Shotaro Maehana, Masato Suzuki, Yuki Yamamoto, Thomas L. Maurissen, Ai Hirabayashi, Takeshi Noda, Makoto Kubo, Shimpei Gotoh, Knut Woltjen: “ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells.” Frontiers in Cell and Developmental Biology. 2023 Dec 8; 11: 1290876.

  2022年度

  1. Tamai K, Sakai K, Yamaki H, Moriguchi K, Igura K, Maehana S, Suezawa T, Takehara K, Hagiwara M, Hirai T, Gotoh S: iPS cell-derived mesenchymal cells that support alveolar organoid development. Cell Rep Methods. 2022 Sep 19; 2(10):100314.
  2. Feng G, Xu Y, Saso S, Sasano S, Kondoh S, Itani H, Gotoh S, Nagao M, Ikejiri M, Tanabe M, Takeuchi K: A Novel Homozygous Variant in GAS2L2 in Two Sisters with Primary Ciliary Dyskinesia. Intern Med. 2022 Sep 15;61(18):2765-2769.
  3. Masui A, Hirai T, Gotoh S: Perspectives of future lung toxicology studies using human pluripotent stem cells. Arch Toxicol. 2022 Feb; 96(2):389-402.
  4. Kawaguchi K, Asai A, Mikawa R, Ogiso N, Sugimoto M: Age-related changes in lung function in National Center for Geriatrics and Gerontology Aging Farm C57Bl/6N mice. Exp Anim. 2022 Oct 26, 10.1538/expanim.22-0109.

  2021年度

  1. Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa Y, Gotoh S. Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology. Sci Transl Med., 13(601): eabb1298, 2021.
  2. Ikeo S, Yamamoto Y, Ikeda K, Sone N, Korogi Y, Tomiyama L, Matsumoto H, Hirai T, Hagiwara M, Gotoh S. Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. Biomaterials, 276:121031, 2021.
  3. Suezawa T, Kanagaki S, Korogi Y, Nakao K, Hirai T, Murakami K, Hagiwara M, Gotoh S. Modeling of lung phenotype of Hermansky-Pudlak syndrome type I using patient-specific iPSCs. Respir Res., 22(1):284, 2021
  4. Suezawa T, Kanagaki S, Moriguchi K, Masui A, Nakao K, Toyomoto M, Tamai K, Mikawa R, Hirai T, Murakami K, Hagiwara M, Gotoh S. Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids. Stem Cell Reports., 14;16(12):2973-2987, 2021

  2020年度

  1. Yamamoto Y, Korogi Y, Hirai T, Gotoh S. A method of generating alveolar organoids using human pluripotent stem cells. Methods Cell Biol., 159: 115-141, 2020.
  2. Kanagaki S, Ikeo S, Suezawa T, Yamamoto Y, Seki M, Hirai T, Hagiwara M, Suzuki Y, Gotoh S. Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition. Stem Cells, 39: 156-169, 2021.