喘息・慢性咳嗽[業績]


  • 2019年
    1. Kanemitsu Y, Matsumoto H, Oguma T, Nagasaki T, Ito I, Izuhara Y, Tajiri T, Iwata T, Mishima M, Niimi A. Independent factors contributing to the daytime and nighttime asthmatic cough refractory to inhaled corticosteroids. J Investig Allergol Clin Immunol. 2019; 29:30-39
    2. Cui S, Ito I, Nakaji H, Iwata T, Matsumoto H, Oguma T, Tajiri T, Nagasaki T, Kanemitsu Y, Izuhara Y, Mishima M, Niimi A. Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model. Respiratory Physiology & Neurobiology 2019; 263:1-8
    3. Sunadome H, Matsumoto H, Izuhara Y, Nagasaki T, Kanemitsu Y, Ishiyama Y, Morimoto C, Oguma T, Ito I, Murase K, Muro S, Kawaguchi T, Tabara Y, Chin K, Matsuda F, Hirai T. Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study. Allergol Int 2019; 69: 46-52
    4. Sato R, Handa T, Matsumoto H, Kubo T, Hirai T. Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study. BMC Pulm Med 2019;19: 247
    5. Ko Y, Asakawa K, Tobino K, Oguma T, Hirai T, Takada T, Takahashi K, Seyama K; Multicenter Lymphangioleiomyomatosis Sirolimus Trial for Safety Study Group.:Quantitative analysis of computed tomography of the lungs in patients with lymphangioleiomyomatosis treated with sirolimus.
      Heliyon. 2020 Feb 6;6(2):e03345. doi: 10.1016/j.heliyon.2020.e03345. eCollection 2020 Feb.
    6. Komatsu-Fujii T, Honda T, Tahara J, Yamashita C, Oguma T, Dainichi T, Kabashima K.:Efficacy of intravenous immunoglobulins for laryngopharyngeal lesions and upper airway obstruction in epidermolysis bullosa acquisita.
J Eur Acad Dermatol Venereol. 2019 Nov 15. doi: 10.1111/jdv.16080.
    7. Mondoñedo JR, Sato S, Oguma T, Muro S, Sonnenberg AH, Zeldich D, Parameswaran H, Hirai T, Suki B.:CT Imaging-Based Low-Attenuation Super Clusters in Three Dimensions and the Progression of Emphysema.
      Chest. 2019 Jan;155(1):79-87.
    8. Matsumoto H. Our obligation to find treatable and untreatable traits in patients with chronic airway diseases. 2019; 57: 293-294
    9. Matsumoto H. Roles of periostin in asthma. In: Kudo A, editor: Periostin. Springer 2019
    2018年
    1. Kanemitsu Y, Matsumoto H, Oguma T, et al. Independent factors contributing to the daytime and nighttime asthmatic cough refractory to inhaled corticosteroids. J Investig Allergol Clin Immunol. 2018:Epub ahead of print.
    2. Suzukawa M, Matsumoto H, Ohshima N, Matsumoto H, et al. Baseline serum CXCL10 and IL-12 levels may predict severe asthmatics’ responsiveness to omalizumab. Respir Med. 2018;134:95-102.
    3. Shikuma K, Chen-Yoshikawa TF, Oguma T, Matsumoto H, et al. Radiologic and Functional Analysis of Compensatory Lung Growth After Living-Donor Lobectomy. Ann Thorac Surg. 2018;105:909-914.
    4. Fujita K, Ito Y, Oguma T, et al. Association between Mycobacterium avium complex lung disease and serum vitamin D status, antimicrobial peptide levels, and bone mineral density. Medicine (Baltimore) 2018;97:e12463
    5. Nagasaki T, Sato K. Kume H, Matsumoto H, Oguma T, et al. The prevalence and disease burden of severe eosinophilic asthma in Japan. J Asthma. 2018. in press
    2017年
    1. Sunadome H, Matsumoto H, Petrova G, Kanemitsu Y, Tohda Y, Horiguchi T, et al. IL4Ralpha and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype. Clin Exp Allergy 2017; 47:998-1006.
    2. Ohta S, Okamoto M, Fujimoto K, Sakamoto N, Takahashi K, Yamamoto H, et al. The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis. PLoS One 2017; 12:e0174547.
    3. Suzukawa M, Matsumoto H, Ohshima N, Tashimo H, Asari I, Tajiri T, et al. Baseline serum CXCL10 and IL-12 levels may predict severe asthmatics’ responsiveness to omalizumab. Respir Med 2017; 134:95-102.
    4. Nagasaki T, Matsumoto H, Oguma T, Ito I, Inoue H, Iwata T, et al. Sensitization to Staphylococcus aureus enterotoxins in smokers with asthma. Ann Allergy Asthma Immunol 2017; 119:408-14 e2.
    5. Nagasaki T, Matsumoto H, Izuhara K. Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma. Allergol Int 2017; 66:404-10.
    6. Matsumoto H, Nagasaki T, Kanemitsu Y, Niimi A, Tabara Y. Reply: Response to Risks and Cough-Aggravating Factors in Prolonged Cough. Ann Am Thorac Soc 2017; 14:1232-3.
    7. Matsumoto H, Kanemitsu Y, Nagasaki T, Tohda Y, Horiguchi T, Kita H, et al. Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes. Ann Allergy Asthma Immunol 2017; 118:197-203.
    8. Matsumoto H, Izuhara Y, Niimi A, Tabara Y, Nagasaki T, Kanemitsu Y, et al. Risks and Cough-Aggravating Factors in Prolonged Cough. Epidemiological Observations from the Nagahama Cohort Study. Ann Am Thorac Soc 2017; 14:698-705.
    9. Hamada S, Tatsumi S, Kobayashi Y, Matsumoto H, Yasuba H. Radiographic Evidence of Sinonasal Inflammation in Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: An Underrecognized Association. J Allergy Clin Immunol Pract 2017; 5:1657-62.
    10. Tohda Y, Iwanaga T, Sano H, Kume H, Hirata K, Ohkura N, et al. Improved quality of life in asthma patients under long-term therapy: Assessed by AHQ-Japan. Int J Clin Pract 2017; 71.
    11. Inoue H, Ito I, Niimi A, Matsumoto H, Oguma T, Tajiri T, et al. Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma. Respir Investig 2017; 55:338-47.
    12. Kamada T, Ito I, Kanemitsu Y, Sato S, Matsumoto H, Niimi A, et al. Three-dimensional imaging forced oscillation technique to assess position-dependent airway obstruction in relapsing polychondritis: A case report. Respir Investig 2017; 55:69-73.
    13. Yamamoto Y, Gotoh S, Korogi Y, Seki M, Konishi S, Ikeo S, et al. Long-term expansion of alveolar stem cells derived from human iPS cells in organoids. Nat Methods 2017; 14:1097-106.
    14. Tanizawa K, Handa T, Nagai S, Niimi A, Oguma T, Kubo T, et al. Comprehensive evaluation of airway involvement in pulmonary sarcoidosis. ERJ Open Res 2017; 3.
    2016年
    1. Nakaji H, Niimi A, Matsuoka H, Iwata T, Cui S, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Chin K, and Mishima M. Airway remodeling associated with cough hypersensitivity as a consequence of persistent cough: An experimental study. Respir Investig. 54:419-27.2016
    2. Tajiri T., Matsumoto H., Gon Y., Ito R., Hashimoto S., Izuhara K., Suzukawa M., Ohta K., Ono J., Ohta S., Ito I., Oguma T., Inoue H., Iwata T., Kanemitsu Y., Nagasaki T., Niimi A., and Mishima M., Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma. Allergy. 71:1474-9. 2016
    3. Muro S., Tabara Y., Matsumoto H., Setoh K., Kawaguchi T., Takahashi M., Ito I., Ito Y., Murase K., Terao C., Kosugi S., Yamada R., Sekine A., Nakayama T., Chin K., Mishima M., and Matsuda F., Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population: The Nagahama Study. Medicine (Baltimore). 95:e3371.2016
    4. Konishi S., Gotoh S., Tateishi K., Yamamoto Y., Korogi Y., Nagasaki T., Matsumoto H., Muro S., Hirai T., Ito I., Tsukita S., and Mishima M., Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells. Stem Cell Reports. 6:18-25.2016
    5. Kanemitsu Y., Niimi A., Matsumoto H., Iwata T., Ito I., Oguma T., Inoue H., Tajiri T., Nagasaki T., Izuhara Y., Petrova G., Birring S.S., and Mishima M., Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma. Allergol Int. 65:320-6.2016
    6. Kanemitsu Y., Matsumoto H., Osman N., Oguma T., Nagasaki T., Izuhara Y., Ito I., Tajiri T., Iwata T., Niimi A., and Mishima M., “Cold air” and/or “talking” as cough triggers, a sign for the diagnosis of cough variant asthma. Respir Investig. 54:413-8. 2016
    7. Izuhara Y., Matsumoto H., Nagasaki T., Kanemitsu Y., Murase K., Ito I., Oguma T., Muro S., Asai K., Tabara Y., Takahashi K., Bessho K., Sekine A., Kosugi S., Yamada R., Nakayama T., Matsuda F., Niimi A., Chin K., and Mishima M., Mouth breathing, another risk factor for asthma: the Nagahama Study. Allergy. 71:1031-6.2016
    8. Inoue H., Ito I., Niimi A., Matsumoto H., Matsuoka H., Jinnai M., Takeda T., Oguma T., Otsuka K., Nakaji H., Tajiri T., Iwata T., Nagasaki T., Kanemitsu Y., and Mishima M., CT-assessed large airway involvement and lung function decline in eosinophilic asthma: The association between induced sputum eosinophil differential counts and airway remodeling. J Asthma. 53:914-21.2016
    9. Hira D., Komase Y., Koshiyama S., Oguma T., Hiramatsu T., Shiraki A., Nishikawa M., Nakanishi M., Tsuji T., Matsumoto H., Ichimura K., Iwanaga T., Morikawa M., Yasuba H., Sugaya F., Arakawa Y., Kobayashi Y., Kato T., Futamura Y., Tsuji F., and Terada T., Problems of elderly patients on inhalation therapy: Difference in problem recognition between patients and medical professionals. Allergol Int. 65:444-0. 2016
    10. Hamada S., Matsumoto H., Kobayashi Y., Asako M., and Yasuba H., Nasal exhalation of inhaled beclomethasone hydrofluoroalkane-134a to treat chronic rhinosinusitis. J Allergy Clin Immunol Pract. 4:751-2.2016
    2015年
    1. Hamada S, Matsumoto H, Kobayashi Y, Asako M, Yasuba H. Nasal exhalation of inhaled beclomethasone HFA to treat chronic rhinosinusitis. Journal of Allergy and Clinical Immunology:In Practice, in press http://dx.doi.org/10.1016/j.jaip.2015.11.018
    2. Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K, Ogawa M. Recent developments regarding periostin in bronchial asthma. Allergol Int, in press. 2015 Sep;64 Suppl:S3-10.
    3. Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M. Mechanical Stimulation by Postnasal Drip Evokes Cough. PLoS One. 2015;10(11):e0141823.
    4. Oguma T, Hirai T, Fukui M, Tanabe N, Marumo S, Nakamura H, Ito H, Sato S,Niimi A, Ito I, Matsumoto H, Muro S, Mishima M. Longitudinal shape irregularity of airway lumen assessed by CT in patients with bronchial asthma and COPD.
      Thorax. 2015;70(8):719-24.
    5. Oguma T, Niimi A, Hirai T, Jinnai M, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Otsuka K, Takeda T, Nakaji H, Chin K, Mishima M. Assessment of Small Airways with Computed Tomography: Mosaic Attenuation or Lung Density?
      Respiration. 2015;89(6):539-49.
    2014年
    1. Tajiri T., Niimi A., Matsumoto H., Ito I., Oguma T., Otsuka K., Takeda T., Nakaji H., Inoue H., Iwata T., Nagasaki T. and Mishima M: Prevalence and clinical relevance of allergic rhinitis in patients with classic asthma and cough variant asthma. Respiration, 87:211-8. 2014
    2. Nagasaki T., Matsumoto H., Kanemitsu Y., Izuhara K., Tohda Y., Kita H., Horiguchi T., Kuwabara K., Tomii K., Otsuka K., Fujimura M., Ohkura N., Tomita K., Yokoyama A., Ohnishi H., Nakano Y., Oguma T., Hozawa S., Ito I., Inoue H., Tajiri T., Iwata T., Izuhara Y., Ono J., Ohta S., Yokoyama T., Niimi A. and Mishima M: Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. J Allergy Clin Immunol, 133:1474-1477 e2. 2014
    3. Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S,Ono J, Iwata T, Matsumoto H, Mishima M: Osteopontin and periostin associates with a 20-year decline of pulmonary function in asthmatics. Am J Respir Crit Care Med, 190; 472-4. 2014
    4. Izuhara Y., Matsumoto H., Kanemitsu Y., Izuhara K., Tohda Y., Horiguchi T., Kita H., Kuwabara K., Tomii K., Otsuka K., Fujimura M., Ohkura N., Tomita K., Yokoyama A., Ohnishi H., Nakano Y., Oguma T., Hozawa S., Nagasaki T., Ito I., Inoue H., Tajiri T., Iwata T., Ono J., Ohta S., Tamari M., Hirota T., Yokoyama T., Niimi A. and Mishima M:GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. Allergy, 69:668-73. 2014
    5. Tajiri T., Niimi A., Matsumoto H., Ito I., Oguma T., Otsuka K., Takeda T., Nakaji H., Inoue H., Iwata T., Nagasaki T., Kanemitsu Y., Izuhara Y. and Mishima M: Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study. Ann Allergy Asthma Immunol, 113: 470-5. 2014
    6. Inoue H., Niimi A., Matsumoto H., Ito I., Oguma T., Takeda T., Matsuoka H., Jinnai M., Otsuka K., Nakaji H., Iwata T., Nagasaki T., Kanemitsu Y., Tajiri T., Chin K., Mishima M: Pathophysiological Characteristics of Asthma in the Elderly: A Comprehensive Study. Ann Allergy Asthma Immunol 113: 527-33. 2014.
    7. Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Tomii K, Fujimura M, Yokoyama A, Nakano Y, Hozawa S, Ito I, Oguma T, Izuhara Y, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M: Using exhaled nitric oxide and serum periostin as a composite marker to identify severe/steroid-insensitive asthma. Am J Respir Crit Care Med, 190; 1149-52. 2014
    8. Matsumoto H: Serum Periostin: A Novel Biomarker for Asthma Management. Allergol Int, 63:153-160. 2014
    9. Kanemitsu Y., Matsumoto H. and Mishima M:Factors Contributing to an Accelerated Decline in Pulmonary Function in Asthma. Allergol Int, 63:181-188. 2014
    10. Kayawake H, Sakai H, Matsumoto H, Date H: Swyer-James syndrome associated with asthma and a giant bulla. Respirol Case Rep 2:150-3. 2014
    2013年
    1. Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M. Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. J Allergy Clin Immunol, in press
    2. Kanemitsu Y, Matsumoto H, Mishima M, on behalf of the KiHAC Respiratory Medicine Group. Factors contributing to an accelerated decline in pulmonary function. Allergol Int, in press.
    3. 第9回アレルギー学会大会賞受賞論文

    4. Matsumoto H. Serum periostin: a novel biomarker for asthma management. Allergol Int, in press
    5. Tajiri T, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Mishima M. Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. Respiration, in press
    6. Oguma T, Hirai T, Niimi A, Matsumoto H, Muro S, Shigematsu M, Nishimura T, Kubo Y, Mishima M. Limitation of airway dimension measurement on images obtained using multi-detector row computed tomography. PLoS One. 2013 Oct 8;8(10):e76381. doi: 10.1371/journal.pone.0076381.
    7. Matsumoto H. Effects of inflammatory cytokines on Ca2+ homeostasis in airway smooth muscle cells. in “Calcium Signaling in Airway Smooth Muscle Cells” Wang YX. ed. Springer, 2013.
    8. Tajiri T, Matsumoto H, Niimi A, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Petrova G, Mishima M. Association of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma. PLoS ONE 2013, 8; 365284. doi:10.1371/journal.pone.0065284
    9. Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids. J Allergy Clin Immunol, in press
    10. Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M. Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma. Ann Allergy Asthma Immunol, 2013, 110:387-8. doi: 10.1016/j.anai.2013.01.024.
    11. Nagasaki T, Matsumoto H. Influences of smoking and aging on allergic airway inflammation in asthma. Allergol Int, 2013, 62:171-9, doi: 10.2332/allergolint.12-RA-0523. 第8回アレルギー学会大会賞受賞論文
    12. Nagasaki T, Matsumoto H, Nakaji H, Niimi A, Ito I, Oguma T, Muro S, Inoue H, Iwata T, Tajiri T, Kanemitsu Y, Mishima M. Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation. Clin Exp Allergy, 2013, 43:608-15, doi: 10.1111/cea.12073, Editor’s Choiceに選ばれました
    13. Nakaji H, Petrova G, Matsumoto H, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Misima M. Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma. Ann Allergy Asthma Immunol, 2013 110:198-203.
    2012年
    1. Matsumoto H, Hirata Y, Otsuka K, Iwata T, Inazumi A, Niimi A., Ito I, Ogawa E, Muro S, Sakai H, Chin K, Oku Y, Mishima M.Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. Cytokine, 2012;57:19-24.
    2. Matsumoto H, Tabuena R, Niimi A, Inoue H. Ito I, Yamaguchi M, Otsuka K, Takeda T, Oguma T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Jinnai M, Matsuoka H, Mishima M. Cough triggers and their pathophysiology in patients with prolonged or chronic cough. Allergol Int, 2012;61:123-32. 第6回アレルギー学会大会賞受賞論文
    3. Otsuka K, Matsumoto H, Niimi A, Muro S, Ito I, Takeda T, Terada K, Yamaguchi M, Matsuoka H, Jinnai M, Oguma T, Nakaji H, Inoue H, Tajiri T, Iwata T, Chin K, Mishima M. Sputum YKL-40 levels and pathophysiology of asthma and chronic obstructive pulmonary disease. Respiration, 2012;83:507-19.
    4. Takemura M, Niimi A, Matsumoto H, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Chin K, Mishima M. Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma.Respiration, 2012;83:308-15.
    5. Ito Y, Hirai T, Maekawa K, Fujita K, Imai S, Tatsumi S, Handa T, Matsumoto H, Muro S, Niimi A, Mishima M. Predictors of 5-year mortality in pulmonary Mycobacterium avium-intracellulare complex disease. Int J Tuberc Lung Dis, 2012;16:408-14.
    2011年
    1. Otsuka K, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Jinnai M, Oguma T, Takeda T, Nakaji H, Chin K, Sasaki K, Aoyama N, Mishima M. Plasma substance P levels in patients with persistent cough. Respiration, 2011;82:431-8.
    2. Nakaji H, Matsumoto H, Niimi A, Handa H, Ito I, Kanai M., Tabata H., Sakai H., Kobashi Y., Mochizuki Y., Chin K, Mishima M. Eosinophils and macrophages are involved in nitrosative stress in chronic eosinophilic pneumonia. Nitric Oxide, 2011;24:173-5.
    3. Matsumoto H, Niimi A, Jinnai M, Nakaji H, Takeda T, Oguma T, Otsuka K, Inoue H, Yamaguchi M, Matsuoka H, Ito I, Hirai T, Chin K, Mishima M. Association of alveolar nitric oxide levels with pulmonary function and its reversibility in stable asthma. Respiration, 2011;81:311-7.
    4. Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Takeda T, Otsuka K, Oguma T, Handa T, Hirai T, Chin K, Mishima M. Long-term changes in airway-wall thickness on computed tomography in asthmatic patients. J Invest Allergol Clin Immunol, 2011;21:113-9.
    5. Kiyokawa H, Matsumoto H, Nakaji H, Niimi A, Ito I, Ono K, Takeda T, Oguma T, Otsuka K, Mishima M. Centrilobular opacities in the asthmatic lung successfully treated wtih inhaled ciclesonide and tiotropium: with assessment of alveolar nitric oxide levels. Allergol Int, 2011;60:381-5.
    6. Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Doi S, Fujita K, Miyatake A, Enomoto T, Miyagawa T, Adachi M, Tanaka M, Niimi A, Matsumoto H, Ito I, Masuko H, Sakamoto T, Hizawa T, Taniguchi M, Lima J, Irvin C, Peters S, Himes B, Litonjua A, Tantisira K, Weiss S, Kamatani N, Nakamura Y, Tamari M. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet 2011;43:893-6.
    7. Niimi A. Structural changes in the airways: Cause or effect of chronic cough. Pulm Pharmacol Ther, 2011;24:328-33.
    8. Niimi A. Cough in asthma. Current Respiratory Medicine Reviews, 2011;7:47-54.
    2010年
    1. Matsuoka H, Niimi A, Matsumoto H, Takemura M, Ueda T, Yamaguchi M, Jinnai M, Inoue H, Ito I, Chin K, Mishima M. Inflammatory subtypes in cough variant asthma: Association with maintenance doses of inhaled corticosteroids. Chest. 2010;138:1418-25.
    2. Kanatani K, Ito I, Al-Delaimy WK, Adachi Y, Mathews WC, Ramsdell JW, Toyama Asian Desert Dust and Asthma Study Team. Desert-dust exposure is associated with increased risk of asthma hospitalization in children. Am J Respir Crit Care Med 2010;182:1475-81.
    3. Nishioka M, Ogawa E, Kinose D, Haruna A, Ohara T, Ito I, Hoshino Y, Ito Y, Matsumoto H, Niimi A, Mio T, Chin K, Hirai T, Muro S, Mishima M. Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells. Respirology 2010;15:669076.
    4. Ito I, Kadowaki S, Tanabe N, Haruna A, Kase M, Yasutomo Y, Tsukino M, Nakai A, Matsumoto H, Niimi A, Chin K, Ichiyama S, Mishima M. Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration: Comparison with imipenem/cilastatin. Pulm Pharmacol Ther. 2010 Oct;23(5):403-410.
    5. Takeda T, Oga T, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Chin K, Mishima M. Relationship between small airway function and health status, dyspnea and disease control in asthma. Respiration 2010;80:120-126.
    6. Jinnai M, Niimi A, Ueda T, Matsuoka H, Takemura M, Yamaguchi M, Otsuka K, Oguma T, Takeda T, Ito I, Matsumoto H, Mishima M. Induced sputum concentrations of mucin in patients with asthma and chronic cough. Chest 2010; 137(5):1122-9.
    2009年
    1. Niimi A, Matsumoto H, Mishima M. Eosinophilic airway disorders associated with chronic cough. Pulm Pharmacol Ther. 2009;22:114-20
    2. Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Chin K, Amitani R, Mishima M. Specific IgE response to Trichophyton and asthma severity. Chest 2009;135:898-903.
    3. Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M. Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. Cough 2009;5:3.
    4. Yamaguchi M, Niimi A, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Matsumoto H, Hirai T, Chin K, Mishima M. Effect of inhaled corticosteroids on small airways in asthma: investigation using impulse oscillometry. Pulm Pharmacol Ther 2009;22:326-32.
    5. Ito I, Fixman ED, Asai K, Yoshida M, Gounni AS, Martin JG, Hamid Q. Platelet-derived growth factor and transforming growth factor-beta modulate the expression of matrix metalloproteinases and migratory function of human airway smooth muscle cells. Clin Exp Allergy. 2009 Sep;39(9):1370-80
    6. Ito I, Ishida T, Togashi K, Niimi A, Koyama H, Ishimori T, Kobayashi H, Mishima M. Differentiation of bacterial and non-bacterial community-acquired pneumonia by thin-section computed tomography. Eur J Radiol. 2009;72:388-95.
    2008年
    1. Takemura M, Quarcoo D, Niimi A, Dinh QT, Geppetti P, Fischer A, Chung KF, Groneberg DA.  Is TRPV-1 a useful target in respiratory diseases? Pulm Pharmacol Ther 2008;21:833-9.
    2. Niimi A. Cough variant asthma: a major cause of chronic cough. Clin Pulm Med 2008;15:189-196.
    3. Ueda T, Niimi A, Matsumoto H, Takemura M, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Minakuchi M, Cheng L, Shirakawa T, Mishima M. TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. J Allergy Clin Immunol 2008;121:659-664.
    4. Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, Jinnai M, Chang L, Otsuka K, Oguma T, Takeda T, Chin K, Mishima M. Patients’ characteristics associated with unsuccessful sputum induction in asthma. J Allergy Clin Immunol 2008;121:774-6.
    5. Yamaguchi M, Niimi A, Matsumoto H, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Chin K, Mishima M. Sputum levels of transforming growth factor-b・ in asthma: Relation to clinicoradiological findings. J Invest Allergol Clin Immunol 2008;18:202-6.
    6. Jinnai M, Niimi A, Takemura M, Matsumoto H, Konda Y, Mishima M. Gastroesophageal reflux-associated chronic cough in an adolescent and the diagnostic implications: a case report. Cough. 2008 Jul 15;4:5.
    7. Matsumoto H. Sputum inflammatory markers in cough variant asthma: therapeutic implications. Multidisciplinary Respiratory Medicine 2008; 3:2217-222.
    2007年
    1. Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M. Atopic features of cough variant asthma and classic asthma with wheezing. Clin Exp Allergy 2007;37:1833-9
    2. Yamaguchi M, Niimi A, Minakuchi M, Matsumoto H, Shimizu K, Chin K, Mishima M. Corticosteroid-induced myopathy mimicking therapy-resistant asthma. Ann Allergy Asthma Immunol 2007;99:371-4.
    3. Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M. Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population. Cough 2007 Jan 8;3:1.
    4. Matsumoto H, Niimi A, Tabuena RP; Takemura M, Ueda T, Yamaguchi M, Matsuoka H, Jinnai M, Chin K, Mishima M. Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. Chest 2007;131:1042-9..
    5. Niimi A. Geography and cough aetiology. Pulm Pharmacol Ther 2007;20:383-387.
    6. Leung SY, Niimi A, Williams AS, Nath P, Blanc FX, Din QT, Chung KF. Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. Cough. 2007 Dec 23;3:10
    7. Matsumoto H, Moir LM, Oliver BG, Burgess JK, Roth M, Black JL, McParland BE. Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma. Thorax. 2007;62:848-54.
    8. Borger P, Matsumoto H, Boustany S, Gencay MM, Burgess JK, King GG, Black JL, Tamm M, Roth M. Disease-specific expression and regulation of CCAAT/enhancer-binding proteins in asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2007;119:98-105.
    9. Ito I, Laporte JD, Fiset PO, Asai K, Yamauchi Y, Martin JG, Hamid Q. Down-regulation of a Disintegrin and Metalloproteinase-33 by Interferon-gamma in Human Airway Smooth Muscle Cells. J Allergy Clin Immunol 2007;119:89-97.
    2006年
    1. Matsumoto H, Niimi A, Takemura M, Ueda T, Tabuena R, Yamaguchi M, Matsuoka H, Hirai T, Muro S, Ito Y, Mio T, Chin K, Nishiyama H, Mishima M. Prognosis of cough variant asthma: a retrospective analysis. J Asthma 2006;43:131-5.
    2. Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, Jinnai M, Muro S, Hirai T, Ito Y, Nakamura T, Mio T, Chin K, Mishima M. High sensitivity C-reactive protein in asthma. Eur Respir J 2006;27:908-12.
    3. Leung SY, Niimi A, Noble A, Oates T, Williams A, Medicherla S, Protter AA, Chung KF. Effect of TGF-β receptor I kinase inhibitor, SD-208, in chronic allergic airway inflammation and remodeling. J Pharmacol Exp Ther. 2006;319:586-94
    4. Ueda T, Niimi A, Matsumoto H, Takemura M, Hirai T, Yamaguchi M, Matsuoka H, Jinnai M, Muro S, Chin K, Mishima M. Role of small airways in asthma: Investigation using high-resolution computed tomography. J Allergy Clin Immunol 2006;118:1019-25.
    5. Committee for the Japanese Respiratory Society Guidelines for Management of Cough; Kohno S, Ishida T, Uchida Y, Kishimoto H, Sasaki H, Shioya T, Tokuyama K, Niimi A, Nishi K, Fujimura M, Matsuse H, Suzaki H. The Japanese Respiratory Society guidelines for management of cough. Respirology 2006;11 Suppl 4:S135-86.
    2005年
    1. Niimi A, Kihara Y, Sumita Y, Okano Y, Tambara K, Fujita M. Cough reflex by ventricular premature contractions. Int Heart J 2005;46:923-6.
    2. Matsumoto H, Niimi A, Takemura M, Ueda T, Minakuchi M, Tabuena RP, Chin K, Mio T, Ito Y, Muro S, Hirai T, Morita S, Fukuhara S, Mishima M. Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma. Thorax 2005;60:277-281.
    3. Niimi A, Torrego A, Nicholson AG, Cosio BG, Oates TB, Chung KF. Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol. 2005;116:565-70
    4. Ito I, Nagai S, Kitaichi M, Nicholson AG, Johkoh T, Noma S, Kim DS, Handa T, Izumi T, Mishima M. Pulmonary Manifestations of Primary Sjogren’s Syndrome: A Clinical, Radiologic, and Pathologic Study. Am J Respir Crit Care Med 2005;172:632-8
    5. Ito I, Nagai S, Handa T, Muro S, Hirai T, Tsukino M, Mishima M. Matrix Metalloproteinase-9 Promoter Polymorphism Associated with Upper Lung Dominant Emphysema. Am J Respir Crit Care Med 2005;172:1378-82.
    2004年
    1. Takemura M, Niimi A, Minakuchi M, Matsumoto H, Ueda T, Chin K, Mishima M. Bronchial dilatation in asthma: relation to clinical and sputum indices. Chest 2004;125:1352-1358.
    2. Niimi A, Matsumoto H, Amitani R, Nakano Y, Sakai H, Takemura M, Ueda T, Chin K, Itoh H, Ingenito EP, Mishima M. Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. Am J Med 2004;116:725-731.
    3. Niimi A, Matsumoto H, Takemura M, Ueda T, Nakano Y, Mishima M. Clinical assessment of airway remodeling in asthma: utility of computed tomography. Clin Rev Allergy Immunol 2004;27:45-57.
    4. Niimi A, Nguyen LT, Usmani O, Mann BS, Chung KF. Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax 2004;59:608-612.
    5. Niimi A, Chung KF. Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough? Pulm Pharmacol Ther 2004;17:441-446.
    6. Groneberg DA, Niimi A, Dinh QT, Cosio B, Hew M, Fischer A, Chung KF. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 2004;170:1276-80
    7. Ueda T, Tabuena R, Matsumoto H, Takemura M, Niimi A, Chin K, Mishima M Successful weaning using noninvasive positive pressure ventilation in a patient with status asthmaticus. Intern Med 2004;43:1060-2.
    8. Ito I, Nagai S, Hoshino Y, Muro S, Hirai T, Tsukino M, Mishima M. Risk and Severity of Chronic Obstructive Pulmonary Disease Is Associated with Gc-globulin 1F Allele. Chest 125: 2004; 63-70.
    2003年以前
    1. Niimi A, Matsumoto H, Ueda T, Takemura M, Suzuki K, Tanaka E, Chin K, Mishima M, Amitani R. Impaired cough reflex in patients with recurrent pneumonia. Thorax 2003;58:152-153.
    2. Niimi A, Matsumoto H, Takemura M, Ueda T, Chin K, Mishima M. Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma. Am J Respir Crit Care Med 2003;168:983-8.
    3. Minakuchi M, Niimi A, Matsumoto H, Amitani R, Mishima M. Chronic eosinophilic pneumonia: treatment with inhaled corticosteroid. Respiration 2003;70:362-366, 2003.
    4. Gibson PG, Fujimura M, Niimi A. Eosinophilic bronchitis: clinical manifestations and implications for treatment. Thorax 2002;57:178-182.
    5. Nakano Y, Muller NL, King GG, Niimi A, Kalloger SE, Mishima M, Pare PD. Quantitative assessment of airway remodeling using high-resolution CT. Chest 2002;122:271s-275s.
    6. Ito I, Ishida T, Mishima M, Osawa M, Arita M, Hashimoto T, Kishimoto T. Familial Cases of Psittacosis: Possible Person-to-person Transmission. Intern Med 41: 2002; 580-3.
    7. Ito I, Ishida T, Hashimoto T, Arita M, Osawa M, Mishima M, Nonoyama S. Hyper-IgM Syndrome with Disseminated Tuberculosis. Scand J Infect Dis 34: 2002; 305-7.
    8. Ito I, Naito J, Kadowaki S, Mishima M, Ishida T, Hongo T, Ma L, Ishii Y, Matsumoto T, Yamaguchi K. Hot spring bath and Legionella pneumonia: an association confirmed by genomic identification. Intern Med 41: 2002; 859-63.
    9. Ito I, Ishida T, Osawa M, Arita M, Hashimoto T, Hongo T, Mishima M. Culturally verified Mycoplasma pneumoniae pneumonia in Japan: a long-term observation from 1979-99. Epidemiol Infect 127: 2001; 365-7.
    10. Ito I, Ishida T, Hashimoto T, Arita M, Osawa M, Yokota T, Ishimori T. Hypopituitarism due to pituitary metastasis of lung cancer: case of a 21-year-old man. Intern Med. 40: 2001; 414-7.
    11. Matsumoto H, Niimi A, Minakuchi M, Izumi T. Serum eosinophil cationic protein measured during exacerbation of asthma. Characteristics of patients with low titres. Clin Exp Allergy 2001;31:637-643
    12. Matsumoto H, Ishihara K, Hasegawa T, Umeda B, Niimi A, Hino M. Effects of inhaled corticosteroid and short courses of oral corticosteroids on bone mineral density in asthmatics: a 4-year longitudinal study. Chest 2001;120:1468-1473.
    13. Niimi A, Matsumoto H, Amitani R, Nakano Y, Mishima M, Minakuchi M, Nishimura K, Itoh H, Izumu T. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am J Respir Crit Care Med 2000;162:1518-1523
    14. Niimi A, Matsumoto H, Minakuchi M, Kitaichi M, Amitani R. Airway remodelling in cough-variant asthma. Lancet 2000;356:564-565.
    15. Matsumoto H, Niimi A, Suzuki K, Kawai M, Matsui Y, Amitani R: Allergic granulomatous angiitis (Churg-Strauss syndrome) associated with allergic bronchopulmonary candidiasis. Respiration 2000;67:577-579.
    16. Matsumoto H, Suzuki K, Watanabe I, Kimoto T, Tsuyuguchi K, Niimi A, Tanaka E, Murayama T, Amitani R. Recurrent hemoptysis in tuberculosis with non-cavitary lung disease as a symptom of mild hemophilia A in a young adult. Intern Med 2000;39:63-65.
    17. Ito I, Ishida T, Hashimoto T, Arita M, Osawa M, Tsukayama C. Familial Cases of Severe Measles Pneumonia. Intern Med 39: 2000; 670-4.
    18. Niimi A, Matsumoto H. Serum measurement of eosinophil cationic protein in the management of asthma. Curr Opin Pulm Med 1999;5:111-117.
    19. Tanaka E, Kimoto T, Tsuyuguchi K, Watanaba I, Matsumoto H, Niimi A, Suzuki K, Murayama T, Amitani R, Kuze F. Effect of clarithromycin regimen for Mycobacterium avium complex pulmonary disease. Am J Respir Crit Care Med 1999;160:866-872.
    20. Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F: Eosinophil cationic protein as a marker of eosinophilic inflammation in asthma. Clin Exp Allergy 1998;28:233-240.
    21. Matsumoto H, Tsuyuguchi K, Suzuki K, Tanaka E, Amitani R, Kuze F. Evaluation of Roche Amplicor PCR assay for Mycobacterium avium complex in bronchial washing. Int J Tuberc Lung Dis 1998; 2: 935-940.
    22. Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F. Eosinophilic inflammation in cough variant asthma. Eur Respir J 1998;11:1064-1069.
    23. Tsuyuguchi K, Amitani R, Matsumoto H, Tanaka E, Suzuki K, Yanagihara K, Mizuno H, Hitomi S, Kuze F. A resected case of Mycobacterium szulgai pulmonary disease. Int J Tuberc Lung Dis 1998;2:258-260.
    24. Niimi A, Amitani R, Watanabe I, Kuze F: Non-asthmatic seasonal cough in an atopic subject: successful treatment with specific immunotherapy.  J Jpn Soc Bronchol 1997;19: 527-530.
    25. Matsumoto H, Suzuki K, Tsuyuguchi K, Tanaka E, Amitani R, Maeda A, Yamamoto K, Sasada M, Kuze F. Interleukin-12 gene expression in human monocyte-derived macrophages stimulated with Mycobacterium bovis BCG: cytokine regulation and effect of NK cells. Infect Immun 1997;65: 4405-4410.
    26. Tanaka E, Amitani R, Niimi A, Suzuki K, Murayama T, Kuze F. Yield of computed tomography and bronchoscopy for the diagnosis of Mycobacterium avium complex pulmonary disease. Am J Respir Crit Care Med 1997;155: 2041-2046.
    27. Suzuki K, Tsuyuguchi K, Matsumoto H, Yamamoto T, Hashimoto T, Tanaka E, Amitani R, Kuze F. Activity of KRM 1648 or rifabutin alone or in combination with clarithromycin against Mycobacterium avium complex in human alveolar macrophages. Int J Tuberc Lung Dis 1997;1:460-467.
    28. Niimi A, Amitani R, Yamada K, Tanaka K, Kuze F. Late respiratory response and associated eosinophilic inflammation induced by repeated exposure to toluene diisocuanate in guinea pigs. J Allergy Clin Immunol 1996;97:1308-1319.
    29. Amitani R, Nishimura K, Niimi A, Kobayashi H, Nawada R, Murayama T, Taguchi H, Kuze F: Mucoid impaction of the bronchi caused by monokaryotic mycelium of Schizophyllum commune. Clin Infect Dis 1996;22:146-148.
    30. Yamada K, Amitani R, Niimi A, Kuze F. Interstitial pneumonitis-like lesions in guinea pigs following repeated exposure to toluene diisocyanate. Eur Respir J 1995;8:1300-1306.
    31. Amitani R, Murayama T, Nawada R, Lee W-J, Niimi A, Suzuki K, Tanaka E, Kuze F. Aspergillus culture filtrates and sputum sols from patients with pulmonary aspergillosis cause damage to human respiratory ciliated epithelium in vitro. Eur Respir J 1995;8: 1681-1687.
    32. Niimi A, Amitani R, Ikeda T, Kubo Y, Tanaka E, Kuze F: Inflammatory bronchial polyps associated with asthma: resolution with inhaled corticosteroid. Eur Respir J 1995;8:1237-1239.